蛛网膜下腔出血后急性微血栓形成：新的治疗靶点？
Acute micro-thrombosis after subarachnoid hemorrhage: A new therapeutic target?
机构信息
Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
出版信息
J Cereb Blood Flow Metab. 2021 Sep;41(9):2470-2472. doi: 10.1177/0271678X211013595. Epub 2021 May 17.
Abstract
Microthrombi formation in the brain following subarachnoid hemorrhage (SAH) has been recognized and suspected to contribute to cerebral ischemia. A recent study found that ultra-early cerebral micro-thrombosis occured four hours after experimental SAH. The number of thrombotic microvessels correlated with brain-blood barrier disruption and neuronal injury. If acute cerebral micro-thrombi also occur in humans, is it time to develop a therapy with systemic thrombolysis for SAH patients?
摘要
蛛网膜下腔出血 (SAH) 后大脑中的微血栓形成已被认识到，并被怀疑导致脑缺血。最近的一项研究发现，实验性 SAH 后 4 小时就出现了超早期脑微血栓。血栓性微血管的数量与血脑屏障破坏和神经元损伤相关。如果急性脑微血栓也发生在人类身上，是否是时候为 SAH 患者开发一种全身性溶栓治疗方法了？
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