蛛网膜下腔出血后急性微血栓形成：新的治疗靶点？
Acute micro-thrombosis after subarachnoid hemorrhage: A new therapeutic target?
机构信息
Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
出版信息
J Cereb Blood Flow Metab. 2021 Sep;41(9):2470-2472. doi: 10.1177/0271678X211013595. Epub 2021 May 17.
Abstract
Microthrombi formation in the brain following subarachnoid hemorrhage (SAH) has been recognized and suspected to contribute to cerebral ischemia. A recent study found that ultra-early cerebral micro-thrombosis occured four hours after experimental SAH. The number of thrombotic microvessels correlated with brain-blood barrier disruption and neuronal injury. If acute cerebral micro-thrombi also occur in humans, is it time to develop a therapy with systemic thrombolysis for SAH patients?
摘要
蛛网膜下腔出血 (SAH) 后大脑中的微血栓形成已被认识到，并被怀疑导致脑缺血。最近的一项研究发现，实验性 SAH 后 4 小时就出现了超早期脑微血栓。血栓性微血管的数量与血脑屏障破坏和神经元损伤相关。如果急性脑微血栓也发生在人类身上，是否是时候为 SAH 患者开发一种全身性溶栓治疗方法了？
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本文引用的文献
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Low-Dose vs Standard-Dose Alteplase in Acute Lacunar Ischemic Stroke: The ENCHANTED Trial.
Neurology. 2021 Mar 16;96(11):e1512-e1526. doi: 10.1212/WNL.0000000000011598. Epub 2021 Feb 3.
2
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3
Microvascular platelet aggregation and thrombosis after subarachnoid hemorrhage: A review and synthesis.
J Cereb Blood Flow Metab. 2020 Aug;40(8):1565-1575. doi: 10.1177/0271678X20921974. Epub 2020 Apr 28.
4
Heparin Treatment in Aneurysmal Subarachnoid Hemorrhage: A Review of Human Studies.
Acta Neurochir Suppl. 2020;127:15-19. doi: 10.1007/978-3-030-04615-6_3.
5
Dual antiplatelet therapy in aneurysmal subarachnoid hemorrhage: association with reduced risk of clinical vasospasm and delayed cerebral ischemia.
J Neurosurg. 2018 Sep;129(3):702-710. doi: 10.3171/2017.5.JNS17831. Epub 2017 Nov 3.
6
Novel Treatments in Neuroprotection for Aneurysmal Subarachnoid Hemorrhage.
Curr Treat Options Neurol. 2016 Aug;18(8):38. doi: 10.1007/s11940-016-0421-6.
7
Effect of recombinant ADAMTS-13 on microthrombosis and brain injury after experimental subarachnoid hemorrhage.
J Thromb Haemost. 2014 Jun;12(6):943-7. doi: 10.1111/jth.12574.
8
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Neurosurg Clin N Am. 2010 Apr;21(2):221-33. doi: 10.1016/j.nec.2009.10.002.
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