Department of Pediatrics, Kahramanmaraş Sütçü İmam University Medical Faculty, Kahramanmaraş, Turkey; Department of Pediatric Cardiology, Kahramanmaraş Sütçü İmam University Medical Faculty, Kahramanmaraş, Turkey.
Department of Pediatrics, Kahramanmaraş Sütçü İmam University Medical Faculty, Kahramanmaraş, Turkey.
Wilderness Environ Med. 2021 Jun;32(2):137-142. doi: 10.1016/j.wem.2021.01.015. Epub 2021 May 12.
Scorpion stings are a major health problem with potentially fatal consequences. Children under the age of 10 y especially face a great risk. Predicting the prognosis is important in reducing mortality and morbidity because it enables the use of early treatment options. In this study, we examine the relationship between proBNP and prognosis in scorpion stings.
This is a retrospective analysis of patients aged ≤18 y who were admitted to the child emergency service with a scorpion sting. We examined the demographical data, clinical findings, laboratory records, treatments, and results of the patients. We classified stage 1 and stage 2 scorpion envenomation as group 1 (mild-moderate) and stage 3 and 4 as group 2 (severe). A t test was used for normally distributed data, and the Mann-Whitney U test was used for nonnormally distributed data. The correlation analysis was done using the Spearman test.
There were 32 (74%) patients in the mild-moderate group and 11 (26%) in the severe group. ProBNP 1 was significantly higher in the severe group at admission (P=0.016). There was no difference between the troponin I values (P=0.051). ProBNP 2 (12th hour) and proBNP 3 (24th hour) were higher in the severe group (P=0.001 and P=0.032, respectively). There was a negative correlation between proBNP and echocardiographic findings involving ejection fraction and shortening fraction (r=-0.703, P=0.002).
In our study, the first proBNP values were significantly higher in the severe group. This suggests that proBNP may be beneficial in predicting prognosis.
蝎子蜇伤是一个严重的健康问题，可能导致致命后果。10 岁以下的儿童面临着巨大的风险。预测预后对于降低死亡率和发病率非常重要，因为它可以使早期治疗选项得到利用。在这项研究中，我们检查了脑利钠肽（proBNP）与蝎子蜇伤预后之间的关系。
这是一项回顾性分析，研究对象为因蝎子蜇伤而入住儿科急诊的≤18 岁患者。我们检查了患者的人口统计学数据、临床发现、实验室记录、治疗方法和结果。我们将 1 期和 2 期蝎子螫伤归类为 1 组（轻度-中度），将 3 期和 4 期归类为 2 组（重度）。正态分布数据采用 t 检验，非正态分布数据采用 Mann-Whitney U 检验。相关性分析采用 Spearman 检验。
轻度-中度组有 32 例（74%）患者，重度组有 11 例（26%）患者。重度组入院时 proBNP 1 显著升高（P=0.016）。肌钙蛋白 I 值无差异（P=0.051）。重度组的 proBNP 2（12 小时）和 proBNP 3（24 小时）更高（P=0.001 和 P=0.032）。proBNP 与涉及射血分数和缩短分数的超声心动图发现呈负相关（r=-0.703，P=0.002）。
在我们的研究中，重度组的初始 proBNP 值显著升高。这表明 proBNP 可能有助于预测预后。
