Sterenborg H J, van der Leun J C
Institute of Dermatology, State University of Utrecht, The Netherlands.
Photodermatol. 1988 Apr;5(2):71-82.
UV-induced epidermal hyperplasia was investigated by measuring the optical transmission of the epidermis of hairless mice exposed daily to ultraviolet radiation. The effects of 2 different radiation sources were investigated: Philips TUV 40W, emitting mainly 254 nm radiation, and Philips TL01 40W, emitting radiation in a narrow band around 312 nm. With both lamps a number of groups of animals were used, each receiving a different daily dose. In the experiments with both types of lamps, hyperplasia appeared to be fully determined by the accumulated dose, irrespective of the daily dose administered. This implies reciprocity between the daily dose and the time elapsed since the first exposure. Moreover, the change of transmission with time and daily dose showed very characteristic behaviour. A simple mathematical model was used to describe these changes. In a previous study we used this model to describe the results of a similar experiment with Westinghouse FS40 sunlamps. The combined data from the present and the previous experiments were used to calculate a first approximation of the action spectrum for UV-induced hyperplasia. In addition, we calculated the dose-response relationship for UV-induced increase in tolerance against ultraviolet radiation for the 3 irradiation sources.
通过测量每日暴露于紫外线辐射的无毛小鼠表皮的光透射率，对紫外线诱导的表皮增生进行了研究。研究了两种不同辐射源的效果：主要发射254nm辐射的飞利浦TUV 40W和在312nm附近窄带发射辐射的飞利浦TL01 40W。使用这两种灯时，都使用了几组动物，每组接受不同的每日剂量。在使用这两种灯的实验中，增生似乎完全由累积剂量决定，而与给予的每日剂量无关。这意味着每日剂量与首次暴露后经过的时间之间存在互易关系。此外，透射率随时间和每日剂量的变化表现出非常典型的行为。使用一个简单的数学模型来描述这些变化。在之前的一项研究中，我们使用这个模型来描述用西屋FS40日光灯进行的类似实验的结果。将本次实验和之前实验的合并数据用于计算紫外线诱导增生的作用光谱的一阶近似值。此外，我们还计算了这三种辐射源紫外线诱导的紫外线耐受性增加的剂量反应关系。
