由携带 emm28 基因型的 A 组链球菌引起的链球菌中毒性休克综合征，该患者在接受子宫癌检查后发病。
Streptococcal Toxic Shock Syndrome Induced by Group A Streptococcus with the emm28 Genotype That Developed after a Uterine Cancer Test.
机构信息
Department of Respiratory Medicine, Nagoya City University West Medical Center, Japan.
Department of Education and Research Center for Advanced Medicine, Nagoya City University Graduate School of Medical Sciences, Japan.
出版信息
Intern Med. 2021 Nov 1;60(21):3481-3483. doi: 10.2169/internalmedicine.6290-20. Epub 2021 May 14.
Abstract
A 69-year-old woman without pre-existing disease visited our hospital due to general malaise, diarrhea, and arthralgia 3 days after a uterine cancer test. We diagnosed her with sepsis of unknown focus and started treatment immediately, but she died 20 hours after the first visit due to multi-organ failure and septic shock. Later, group A streptococcus was detected from the blood culture, and streptococcal toxic shock syndrome (STSS) was diagnosed. The strain had the emm28 genotype and a mutation in csrR with increased NADase activity. These virulence factors were considered to be related to STSS development in this patient.
摘要
一位 69 岁的无既往病史女性患者因子宫癌检查后 3 天出现全身不适、腹泻和关节痛就诊于我院。我们诊断为不明原因的脓毒症，并立即开始治疗，但患者在首次就诊后 20 小时因多器官功能衰竭和感染性休克死亡。后来，从血培养中检出 A 群链球菌，诊断为链球菌中毒性休克综合征（STSS）。该菌株具有 emm28 基因型和 csrR 突变，导致 NADase 活性增加。这些毒力因子被认为与该患者 STSS 的发生有关。
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