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Homologous role of CovRS two-component regulatory system in NAD -glycohydrolase activity in Streptococcus dysgalactiae subsp. equisimilis as in Streptococcus pyogenes.CovRS双组分调节系统在马链球菌兽疫亚种中NAD-糖水解酶活性方面的同源作用与化脓性链球菌中的情况相同。
APMIS. 2019 Feb;127(2):87-92. doi: 10.1111/apm.12914.
2
Epidemiology of Invasive Group A Streptococcal Infections in the United States, 2005-2012.2005 - 2012年美国侵袭性A组链球菌感染的流行病学
Clin Infect Dis. 2016 Aug 15;63(4):478-86. doi: 10.1093/cid/ciw248. Epub 2016 Apr 22.
3
Increased prevalence of group A streptococcus isolates in streptococcal toxic shock syndrome cases in Japan from 2010 to 2012.2010年至2012年日本链球菌中毒性休克综合征病例中A组链球菌分离株的患病率增加。
Epidemiol Infect. 2015 Mar;143(4):864-72. doi: 10.1017/S0950268814001265.
4
Increased incidence of invasive group A streptococcal disease in Ireland, 2012 to 2013.2012 年至 2013 年爱尔兰侵袭性 A 组链球菌病发病率上升。
Euro Surveill. 2013 Aug 15;18(33):20556. doi: 10.2807/1560-7917.es2013.18.33.20556.
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Updated model of group A Streptococcus M proteins based on a comprehensive worldwide study.基于全球综合研究的 A 组链球菌 M 蛋白更新模型。
Clin Microbiol Infect. 2013 May;19(5):E222-9. doi: 10.1111/1469-0691.12134. Epub 2013 Mar 7.
6
Invasive group a streptococcal disease: epidemiology, pathogenesis and management.侵袭性 A 组链球菌病:流行病学、发病机制和治疗。
Drugs. 2012 Jun 18;72(9):1213-27. doi: 10.2165/11634180-000000000-00000.
7
Invasive group A streptococcal infections in adults, France (2006-2010).成人侵袭性 A 组链球菌感染,法国(2006-2010 年)。
Clin Microbiol Infect. 2012 Jul;18(7):702-10. doi: 10.1111/j.1469-0691.2011.03624.x. Epub 2011 Aug 29.
8
Highly frequent mutations in negative regulators of multiple virulence genes in group A streptococcal toxic shock syndrome isolates.A 组溶血性链球菌中毒性休克综合征分离株中多个毒力基因负调控因子的高频突变。
PLoS Pathog. 2010 Apr 1;6(4):e1000832. doi: 10.1371/journal.ppat.1000832.
9
The streptococcal M protein: a highly versatile molecule.链球菌 M 蛋白:一种高度多功能的分子。
Trends Microbiol. 2010 Jun;18(6):275-82. doi: 10.1016/j.tim.2010.02.007. Epub 2010 Mar 27.
10
Clinical and microbiological characteristics of severe Streptococcus pyogenes disease in Europe.欧洲严重化脓性链球菌疾病的临床和微生物学特征
J Clin Microbiol. 2009 Apr;47(4):1155-65. doi: 10.1128/JCM.02155-08. Epub 2009 Jan 21.

由携带 emm28 基因型的 A 组链球菌引起的链球菌中毒性休克综合征,该患者在接受子宫癌检查后发病。

Streptococcal Toxic Shock Syndrome Induced by Group A Streptococcus with the emm28 Genotype That Developed after a Uterine Cancer Test.

机构信息

Department of Respiratory Medicine, Nagoya City University West Medical Center, Japan.

Department of Education and Research Center for Advanced Medicine, Nagoya City University Graduate School of Medical Sciences, Japan.

出版信息

Intern Med. 2021 Nov 1;60(21):3481-3483. doi: 10.2169/internalmedicine.6290-20. Epub 2021 May 14.

DOI:10.2169/internalmedicine.6290-20
PMID:33994434
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8627819/
Abstract

A 69-year-old woman without pre-existing disease visited our hospital due to general malaise, diarrhea, and arthralgia 3 days after a uterine cancer test. We diagnosed her with sepsis of unknown focus and started treatment immediately, but she died 20 hours after the first visit due to multi-organ failure and septic shock. Later, group A streptococcus was detected from the blood culture, and streptococcal toxic shock syndrome (STSS) was diagnosed. The strain had the emm28 genotype and a mutation in csrR with increased NADase activity. These virulence factors were considered to be related to STSS development in this patient.

摘要

一位 69 岁的无既往病史女性患者因子宫癌检查后 3 天出现全身不适、腹泻和关节痛就诊于我院。我们诊断为不明原因的脓毒症,并立即开始治疗,但患者在首次就诊后 20 小时因多器官功能衰竭和感染性休克死亡。后来,从血培养中检出 A 群链球菌,诊断为链球菌中毒性休克综合征(STSS)。该菌株具有 emm28 基因型和 csrR 突变,导致 NADase 活性增加。这些毒力因子被认为与该患者 STSS 的发生有关。