新型4-烷基-3-硝基-1,4-二氢氮杂环并[5,1-][1,2,4]三嗪-4-醇的合成方法及抗病毒活性
Methods of Synthesis and Antiviral Activity of New 4-Alkyl-3-Nitro-1,4-Dihydroazolo[5,1-][1,2,4]Triazin-4-ols.
作者信息
Drokin Roman A, Tiufiakov Dmitrii V, Voinkov Egor K, Slepukhin Pavel A, Ulomsky Evgeny N, Esaulkova Yana L, Volobueva Alexandrina S, Lantseva Kristina S, Misyurina Mariya A, Zarubaev Vladimir V, Rusinov Vladimir L
机构信息
Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St, Yekaterinburg, 620002 Russia.
Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St, Yekaterinburg, 620108 Russia.
出版信息
Chem Heterocycl Compd (N Y). 2021;57(4):473-478. doi: 10.1007/s10593-021-02926-2. Epub 2021 May 12.
UNLABELLED
An azo coupling reaction of α-nitro ketones with 5-diazoazoles was used to obtain 4-alkyl-3-nitro-1,4-dihydroazolo[5,1-][1,2,4]triazines, which were characterized with respect to their antiviral activity against influenza and Coxsackie B3 viruses.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1007/s10593-021-02926-2.
未标记
利用α-硝基酮与5-重氮唑的偶氮偶联反应来获得4-烷基-3-硝基-1,4-二氢唑并[5,1-][1,2,4]三嗪，并对其针对流感病毒和柯萨奇B3病毒的抗病毒活性进行了表征。
补充信息
在线版本包含可在10.1007/s10593-021-02926-2获取的补充材料。
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