抗病毒药物三氮唑核苷，用氢、碳和氮稳定同位素进行选择性标记。合成及性质。
Antiviral drug Triazavirin, selectively labeled with H, C, and N stable isotopes. Synthesis and properties.
作者信息
Shestakova Tatyana S, Deev Sergey L, Khalymbadzha Igor А, Rusinov Vladimir L, Paramonov Alexander S, Arseniev Alexander S, Shenkarev Zakhar O, Charushin Valery N, Chupakhin Oleg N
机构信息
Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira St., Yekaterinburg, 620002 Russia.
Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 Sofyi Kovalevskoi St., Yekaterinburg, 620108 Russia.
出版信息
Chem Heterocycl Compd (N Y). 2021;57(4):479-482. doi: 10.1007/s10593-021-02927-1. Epub 2021 May 12.
UNLABELLED
Isotope-labeled antiviral drug Triazavirin containing H, C, and N atoms in its structure has been synthesized. CHI and KSCN served as donors of C isotopes. The use of С-MeI containing H atoms made it possible to additionally incorporate deuterium labels into the structure of the compound. The N atoms were incorporated using N-enriched sodium nitrite, aminoguanidine carbonate, and ethyl nitroacetate. The resulting H,C,N-Triazavirin was characterized by NMR spectroscopy.
SUPPLEMENTARY INFORMATION
The online version contains supplementary material available at 10.1007/s10593-021-02927-1.
未标记
已合成结构中含有氢、碳和氮原子的同位素标记抗病毒药物三氮唑核苷。CHI和KSCN用作碳同位素供体。使用含有氢原子的С-甲基碘使得能够将氘标记额外引入化合物结构中。使用富含氮的亚硝酸钠、氨基胍碳酸盐和硝基乙酸乙酯引入氮原子。所得的H、C、N-三氮唑核苷通过核磁共振光谱进行表征。
补充信息
在线版本包含可在10.1007/s10593-021-02927-1获取的补充材料。
Zotero 插件