Endo T, Nakaya S, Kimura R
Faculty of Pharmaceutical Science, Higashi Nippon Gakuen University, Hokkaido, Japan.
Pharmacol Toxicol. 1988 Jul;63(1):8-15. doi: 10.1111/j.1600-0773.1988.tb00900.x.
A correlation of mercury absorption with water absorption was investigated by using the perfusion of rat small intestine with buffers containing 10(-4) M HgCl2. With a decrease in the osmolarity of the buffers or with increases in the sodium ion and urea concentrations in the buffers, absorption of water and mercury and accumulation of mercury in the intestinal tissue increased, and the increases in mercury absorption and accumulation were found to correlate with the increase in water absorption. Both the decrease in osmolarity and the increase in sodium ion concentration increased mercury accumulation in the epithelial cell after the perfusion. But these changes did not alter the mercury distribution in subcellular fractions. The results suggest that the increase in water absorption due to the hyptonicity or the increase in concentration of sodium ion or urea increases the mercury absorption and accumulation in the epithelial cell without change in the distributional pattern of mercury in the cell.
通过用含10⁻⁴M HgCl₂的缓冲液灌注大鼠小肠，研究了汞吸收与水吸收之间的相关性。随着缓冲液渗透压的降低或缓冲液中钠离子和尿素浓度的增加，水和汞的吸收以及汞在肠组织中的积累增加，并且发现汞吸收和积累的增加与水吸收的增加相关。灌注后，渗透压的降低和钠离子浓度的增加均增加了上皮细胞中汞的积累。但这些变化并未改变汞在亚细胞组分中的分布。结果表明，由于低渗性或钠离子或尿素浓度的增加导致的水吸收增加，会增加上皮细胞中汞的吸收和积累，而细胞中汞的分布模式不变。
