Endo T, Nakaya S, Kimura R, Murata T
Toxicol Appl Pharmacol. 1984 Jun 30;74(2):223-9. doi: 10.1016/0041-008x(84)90146-7.
The absorption of inorganic mercury in rats was studied by using ligated gastrointestinal segments and perfusion of small intestine. Poorly soluble mercuric oxide (HgO) as well as mercuric chloride (HgCl2) was absorbed from the ligated segments in the following order: duodenum greater than stomach = jejunum = ileum. The ligation of bile duct decreased the duodenal absorption of HgCl2, while no change was observed in that of HgO. In the bile duct-ligated rats, the coadministration of bile increased the absorption of HgCl2 compared to that in rats without the ligation. The absorption of HgCl2 was increased with an increase of pH of the solution perfused into small intestine. These results suggest that the alkalinity of bile promotes the absorption of HgCl2.
通过使用结扎的胃肠道段和小肠灌注法研究了大鼠体内无机汞的吸收情况。难溶性氧化汞（HgO）以及氯化汞（HgCl₂）从结扎段按以下顺序被吸收：十二指肠＞胃 = 空肠 = 回肠。结扎胆管会降低十二指肠对HgCl₂的吸收，而对HgO的吸收未观察到变化。在胆管结扎的大鼠中，与未结扎的大鼠相比，同时给予胆汁会增加HgCl₂的吸收。随着灌注到小肠的溶液pH值升高，HgCl₂的吸收增加。这些结果表明胆汁的碱性促进了HgCl₂的吸收。
