利用光学相干断层扫描血管造影术评估家族性渗出性玻璃体视网膜病变中的黄斑无血管区
Evaluation of the Foveal Avascular Zone in Familial Exudative Vitreoretinopathy Using Optical Coherence Tomography Angiography.
作者信息
Hasegawa Tetsuya, Hirato Misaki, Kobashi Chieko, Yamaguchi Aya, Takagi Rina, Tanaka Yoshiaki, Kaburaki Toshikatsu, Kakehashi Akihiro
机构信息
Department of Ophthalmology, Saitama Medical Center Jichi Medical University, Saitama-shi, Saitama-ken, Japan.
出版信息
Clin Ophthalmol. 2021 May 7;15:1913-1920. doi: 10.2147/OPTH.S305520. eCollection 2021.
PURPOSE
To evaluate the foveal avascular zone (FAZ) and retinal structure in familial exudative vitreoretinopathy (FEVR).
PATIENTS AND METHODS
Eighteen eyes with stage 1 or 2 FEVR and 20 control eyes were evaluated. The central retinal thickness (CRT), foveal inner retinal thickness (IRT), surface retinal vessel density (SRVD), and deep retinal vessel density (DRVD) were measured using optical coherence tomography. The FAZ area was calculated using ImageJ software. The equivalent spherical value (SE) and axial length (AL) were measured.
RESULTS
The CRT (232.5±3.086 vs 211±12.6325 μm; =0.003) and foveal IRT (15.83±13.95 vs 0.9±4.02 μm; =0.002) were thicker in the FEVR group than in the control group. The surface FAZ area (0.265±0.08 vs 0.364±0.09 mm; =0.004) and the deep FAZ area (0.364±0.1 vs 0.484±0.11 mm; =0.03) were smaller in the FEVR group than in the control group. The SRVD values did not differ among the sectors, but the DRVD was higher in the FEVR group except for the inferior sector (superior, =0.027; inferior, =0.88; temporal, =0.035; nasal, =0.027). The SE and AL did not differ between the two groups. There were no correlations between the surface and deep layer FAZ area and age, CRT, SE, and AL. The surface, deep FAZ area, and foveal IRT were correlated negatively (surface, r = -0.47, =0.033; deep layer FAZ area, r = -0.46, =0.037).
CONCLUSION
Eyes with FEVR have a smaller FAZ because the vascular structure in the inner retina remained in the fovea.
目的
评估家族性渗出性玻璃体视网膜病变（FEVR）患者的黄斑无血管区（FAZ）及视网膜结构。
患者与方法
对18只1或2期FEVR患眼及20只对照眼进行评估。使用光学相干断层扫描测量中心视网膜厚度（CRT）、黄斑内层视网膜厚度（IRT）、视网膜表面血管密度（SRVD）及视网膜深层血管密度（DRVD）。使用ImageJ软件计算FAZ面积。测量等效球镜值（SE）及眼轴长度（AL）。
结果
FEVR组的CRT（232.5±3.086 vs 211±12.6325μm；P = 0.003）及黄斑IRT（15.83±13.95 vs 0.9±4.02μm；P = 0.002）比对照组更厚。FEVR组的视网膜表面FAZ面积（0.265±0.08 vs 0.364±0.09mm²；P = 0.004）及视网膜深层FAZ面积（0.364±0.1 vs 0.484±0.11mm²；P = 0.03）比对照组更小。各象限的SRVD值无差异，但FEVR组除下方象限外，其他象限的DRVD更高（上方，P = 0.027；下方，P = 0.88；颞侧，P = 0.035；鼻侧，P = 0.027）。两组间的SE及AL无差异。视网膜表面及深层FAZ面积与年龄、CRT、SE及AL之间无相关性。视网膜表面、深层FAZ面积与黄斑IRT呈负相关（表面，r = -0.47，P = 0.033；深层FAZ面积，r = -0.46，P = 0.037）。
结论
FEVR患眼的FAZ较小，因为黄斑区内层视网膜的血管结构得以保留。
Zotero 插件