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家族性渗出性玻璃体视网膜病变伴内界膜持续存在的光学相干断层扫描血管造影和视网膜血管角度的特征。

The Characteristic of Optical Coherence Tomography Angiography and Retinal Arteries Angle in Familial Exudative Vitreoretinopathy with Inner Retinal Layer Persistence.

机构信息

Department of Ophthalmology, Hangzhou Traditional Chinese Medicine Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China.

Department of Retina Centre, Affiliated Eye Hospital of Wenzhou Medical University, Hangzhou, China.

出版信息

Curr Eye Res. 2023 Sep;48(9):850-856. doi: 10.1080/02713683.2023.2213867. Epub 2023 Jun 11.

Abstract

PURPOSE

To compare the angle of retinal arteries and macular vessel density and foveal avascular zone (FAZ) in early stage familial exudative vitreoretinopathy (FEVR) patients with inner retinal layer (IRL) persistence with FEVR patients without IRL persistence and normal people.

METHODS

This study enrolled 113 early stage FEVR patients and 55 age-matched normal subjects. FEVR patients were divided into IRL group and non-IRL group based on the presence or absence of IRL in fovea. The angle of superior temporal and inferior temporal branch retinal arteries on ultra-wide-field fundus images were measured. Superficial and deep vessel density of whole image, fovea and parafovea, the area and perimeter of FAZ, A-circularity index (AI, perimeter/standard circle perimeter with equal area) and vessel density around the 300-μm width of the FAZ (FD), central macular thickness (CMT) on 3 mm × 3mm OCTA were measured.

RESULTS

30 FEVR patients in IRL group, 83 FEVR patients in non-IRL group, 55 normal people in control group were evaluated. BCVA were worst in IRL group ( < .001). The angle of retinal arteries was smaller in FEVR groups ( < .001) and were smallest in IRL group ( < .001). Superficial and deep vessel density of whole and parafovea area in FEVR patients were significantly lower than that in normal people ( < .05), AI were biggest ( = .01) and FD were smallest in IRL group ( < .001). CMT in IRL group were thicker than non-IRL group and control group ( < .05).

CONCLUSION

Worse BCVA, smaller angle of retinal arteries (more vessels traction), lower macular vessel density, smaller and more irregular FAZ and thicker CMT were observed in FEVR patients with IRL persistence even in early stage.

摘要

目的

比较早期家族渗出性玻璃体视网膜病变(FEVR)患者伴内视网膜层(IRL)持续存在与不伴 IRL 持续存在以及正常人群的视网膜动脉角度、黄斑血管密度和中心凹无血管区(FAZ)。

方法

本研究纳入了 113 例早期 FEVR 患者和 55 名年龄匹配的正常对照。根据黄斑中心凹是否存在 IRL,FEVR 患者分为 IRL 组和非 IRL 组。测量超宽视野眼底图像上颞上和颞下分支视网膜动脉的角度。测量全像、黄斑和旁黄斑区、FAZ 区面积和周长、A 圆形度指数(AI,周长/标准圆周长,面积相等)和 FAZ 300μm 宽度周围的血管密度(FD)、3mm×3mm OCTA 中央黄斑厚度(CMT)。

结果

IRL 组 30 例、非 IRL 组 83 例、对照组 55 例 FEVR 患者纳入研究。IRL 组最佳矫正视力(BCVA)最差( < .001)。FEVR 组视网膜动脉角度较小( < .001),其中 IRL 组最小( < .001)。FEVR 患者的全像和旁黄斑区浅层和深层血管密度明显低于正常对照组( < .05),AI 最大( = .01),IRL 组 FD 最小( < .001)。IRL 组 CMT 比非 IRL 组和对照组更厚( < .05)。

结论

即使在早期,伴 IRL 持续存在的 FEVR 患者的 BCVA 更差,视网膜动脉角度更小(更多血管牵拉),黄斑血管密度更低,FAZ 更小且更不规则,CMT 更厚。

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