Yengil Erhan, Onlen Yusuf, Ozer Cahit, Hambolat Mustafa, Ozdogan Mehmet
Department of Family Medicine, Hatay Mustafa Kemal University School of Medicine, Hatay, Turkey.
Department of Infectious Disease and Clinical Microbiology, Hatay Mustafa Kemal University School of Medicine, Hatay, Turkey.
Int J Gen Med. 2021 May 7;14:1757-1762. doi: 10.2147/IJGM.S309022. eCollection 2021.
The aim of this study was to investigate the effectiveness of booster vaccination of adults with measles-mumps-rubella in the COVID-19 infection rates.
In order to investigate this hypothesis, we tested COVID-19 positivity rate through PCR assay on the participants (n=245; male), who had to share the same student accommodation together with the same dining hall to provide governmental service. Participants were divided into two groups based on their booster vaccination status with measles-mumps-rubella: the non-vaccinated group (n=207) and the vaccinated group (n=38). The rate of COVID-19 seropositivity, age, body mass index (BMI), active smoking and presence of comorbidity were also measured and recorded.
All of the participants were healthy, and age distribution, comorbidity rates, active smoking status and BMI did not vary significantly among the two groups (=0.305, =0.594, =0.280, and =0.922, respectively). About 36.7% (n=90) of the participants were found to be COVID-19 positive by PCR among which the non-vaccinated cases had higher rates of COVID-19 seropositivity than the vaccinated cases (40.6% vs 15.8%) (OR=3.6, 95%CI: 1.5-9.0, =0.004).
Based on these results, we cautiously predict that immunity produced by MMR vaccination boosters may provide some degree of protection against COVID-19 in the adult population.
本研究旨在调查成人接种麻疹-腮腺炎-风疹加强疫苗对新冠病毒感染率的影响。
为了验证这一假设，我们通过聚合酶链反应（PCR）检测了参与人员（n = 245；男性）的新冠病毒阳性率，这些人员因提供政府服务而共用学生宿舍和食堂。根据麻疹-腮腺炎-风疹加强疫苗接种状况，将参与者分为两组：未接种组（n = 207）和接种组（n = 38）。同时测量并记录了新冠病毒血清阳性率、年龄、体重指数（BMI）、当前吸烟情况和合并症情况。
所有参与者均健康，两组之间的年龄分布、合并症发生率、当前吸烟状况和BMI无显著差异（分别为P = 0.305、P = 0.594、P = 0.280和P = 0.922）。通过PCR检测发现，约36.7%（n = 90）的参与者新冠病毒呈阳性，其中未接种者的新冠病毒血清阳性率高于接种者（40.6%对15.8%）（比值比=3.6，95%置信区间：1.5 - 9.0，P = 0.004）。
基于这些结果，我们谨慎预测，麻疹-腮腺炎-风疹加强疫苗产生的免疫力可能为成年人群提供一定程度的新冠病毒防护。
