van Groen Thomas, Kadish Inga, Popović Natalija, Caballero Bleda María, Baño-Otalora Beatriz, Rol María Angeles, Madrid Juan Antonio, Popović Miroljub
Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL, United States.
Department of Human Anatomy and Psychobiology, Faculty of Medicine, University of Murcia, Murcia, Spain.
Front Neuroanat. 2021 Apr 29;15:656882. doi: 10.3389/fnana.2021.656882. eCollection 2021.
It has been demonstrated that in adulthood rodents show newly born neurons in the subgranular layer (SGL) of the dentate gyrus (DG), and in the subventricular zone (SVZ). The neurons generated in the SVZ migrate through the rostral migratory stream (RMS) to the olfactory bulb. One of the markers of newly generated neurons is doublecortin (DCX). The degu similarly shows significant numbers of DCX-labeled neurons in the SGL, SVZ, and RMS. Further, most of the nuclei of these DCX-expressing neurons are also labeled by proliferating nuclear antigen (PCNA) and Ki67. Finally, whereas in rats and mice DCX-labeled neurons are predominantly present in the SGL and SVZ, with only a few DCX neurons present in piriform cortex, the degu also shows significant numbers of DCX expressing neurons in areas outside of SVZ, DG, and PC. Many areas of neocortex in degu demonstrate DCX-labeled neurons in layer II, and most of these neurons are found in the limbic cortices. The DCX-labeled cells do not stain with NeuN, indicating they are immature neurons.
已经证明，成年啮齿动物在齿状回（DG）的颗粒下层（SGL）和脑室下区（SVZ）中显示出新生成的神经元。在SVZ中产生的神经元通过吻侧迁移流（RMS）迁移到嗅球。新生神经元的标志物之一是双皮质素（DCX）。八齿鼠同样在SGL、SVZ和RMS中显示出大量DCX标记的神经元。此外，这些表达DCX的神经元的大多数细胞核也被增殖细胞核抗原（PCNA）和Ki67标记。最后，虽然在大鼠和小鼠中，DCX标记的神经元主要存在于SGL和SVZ中，梨状皮质中只有少数DCX神经元，但八齿鼠在SVZ、DG和PC以外的区域也显示出大量表达DCX的神经元。八齿鼠新皮质的许多区域在II层显示出DCX标记的神经元，并且这些神经元中的大多数存在于边缘皮质中。DCX标记的细胞不被NeuN染色，表明它们是未成熟的神经元。
