Roth Cameron A, Da Lomba Tony, Dadwani Rahul, Dahm James, Strelzow Jason
Department of Orthopaedic Surgery, University of Chicago, 5841 S. Maryland Ave, MC 3079, Chicago, IL, 60637, USA.
Pritzker School of Medicine, University of Chicago, Chicago, IL, USA.
Ther Adv Musculoskelet Dis. 2021 Apr 22;13:1759720X211002582. doi: 10.1177/1759720X211002582. eCollection 2021.
This study aims to develop a simple diagnostic criterion that could be used to justify arthrocentesis in adults with suspected septic arthritis. Our hypothesis is that no single factor will be predictive for a decision to aspirate a questionable septic joint.
A prospective observational cohort study was performed at a Level 1 Trauma institution including all patients over the age of 18 years referred to Orthopaedics through the Emergency Department or inpatient orthopaedic consultations for a suspected septic joint. Patient information recorded was age, laboratory markers (white blood cell count, erythrocyte , physical exam findings (fever, pain with range-of-motion), and presence of smoking, diabetes, end-stage renal disease (ESRD) on dialysis, and body mass index > 30. Continuous data was analyzed using logistic regression, and nominal data was analyzed using a two-tailed Fisher's exact test.
A total of 128 patients met inclusion criteria for this study; 71 patients underwent arthrocentesis for suspected septic joint. On analysis of risk factors, the demographics, laboratory markers, physical exam and comorbidities were not significant between the two groups. On subset analysis of the septic joints, we found the only risk factor to be significantly predictive of whether a joint was septic was the presence of ESRD on dialysis ( = 0.042).
Past data have looked solely at predictive risk factors for septic arthritis; however, this study aims to predict what drives physicians towards aspirating a joint even before it is determined to be septic. We found no single factor was predictive of joint aspiration. Only ESRD on dialysis is predictive of whether a joint with concern for septic arthritis would ultimately be septic in our institution. The decision to aspirate continues to be best determined by clinician judgment in light of experience and available clinical information.
本研究旨在制定一种简单的诊断标准,用于判定疑似脓毒性关节炎的成人患者是否需要进行关节穿刺术。我们的假设是,没有单一因素能够预测是否应对可疑的脓毒性关节进行穿刺。
在一家一级创伤机构进行了一项前瞻性观察队列研究,纳入所有18岁以上因疑似脓毒性关节通过急诊科转诊至骨科或接受骨科住院会诊的患者。记录的患者信息包括年龄、实验室指标(白细胞计数、红细胞……)、体格检查结果(发热、活动时疼痛),以及是否吸烟、患有糖尿病、接受透析的终末期肾病(ESRD)和体重指数>30。连续数据采用逻辑回归分析,名义数据采用双尾Fisher精确检验分析。
共有128例患者符合本研究的纳入标准;71例患者因疑似脓毒性关节接受了关节穿刺术。在分析危险因素时,两组患者的人口统计学、实验室指标、体格检查和合并症方面均无显著差异。在对脓毒性关节的亚组分析中,我们发现唯一能显著预测关节是否为脓毒性的危险因素是接受透析的ESRD(=0.042)。
既往数据仅关注脓毒性关节炎的预测危险因素;然而,本研究旨在预测是什么因素促使医生在关节被判定为脓毒性之前就对其进行穿刺。我们发现没有单一因素能预测关节穿刺。在我们机构中,只有接受透析的ESRD能预测疑似脓毒性关节炎的关节最终是否为脓毒性。是否进行穿刺的决定仍最好由临床医生根据经验和现有临床信息进行判断。