Jain Aayush, Madu Chikezie O, Lu Yi
Departments of Biological Sciences, University of Memphis, Memphis, TN 38152. USA.
Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN 38163. USA.
J Cancer. 2021 Apr 30;12(12):3686-3700. doi: 10.7150/jca.57776. eCollection 2021.
Cancer is one of the leading causes of death across the world. Although conventional cancer treatments such as chemotherapy and radiotherapy have effectively decreased cancer progression, they come with many dose-limiting side-effects. Phytochemicals that naturally occur in spices, fruits, vegetables, grains, legumes, and other common foods are surprisingly effective complements to conventional cancer treatments. These biologically active compounds demonstrate anticancer effects via cell signaling pathway interference in cancerous cells. In addition, phytochemicals protect non-cancerous cells from chemotherapy-induced side-effects. This paper addresses the not only the potential of phytochemicals quercetin, isoflavones, curcumin, catechins, and hesperidin in terms of cancer treatment and protection against side-effects of chemotherapy, but also methods for increasing phytochemical bioavailability.
癌症是全球主要死因之一。尽管化疗和放疗等传统癌症治疗方法有效地减缓了癌症进展，但它们伴随着许多剂量限制副作用。天然存在于香料、水果、蔬菜、谷物、豆类和其他常见食物中的植物化学物质是传统癌症治疗方法令人惊讶的有效补充。这些生物活性化合物通过干扰癌细胞中的细胞信号通路发挥抗癌作用。此外，植物化学物质可保护非癌细胞免受化疗引起的副作用。本文不仅探讨了槲皮素、异黄酮、姜黄素、儿茶素和橙皮苷等植物化学物质在癌症治疗以及预防化疗副作用方面的潜力，还探讨了提高植物化学物质生物利用度的方法。
