German Centre for Integrative Biodiversity Research (iDiv), Halle-Jena-Leipzig, Germany.
Department of Microbiology, Nasarawa State University, Keffi, Nigeria.
Pan Afr Med J. 2021 Feb 18;38:186. doi: 10.11604/pamj.2021.38.186.27953. eCollection 2021.
Despite the adoption and use of different infection prevention and control measures, the coronavirus disease (COVID-19) pandemic keeps surging on with globally increasing morbidities and mortalities. The lack of a specific therapeutic intervention against COVID-19 warrants the use of non-conventional potent alternatives. In recent times, probiotics have shown to mitigate numerous health challenges, including animal and human infectious diseases through competitive exclusion or antagonism of pathogens, modulation of host-microbiota, secretion of antimicrobial compounds and stimulation of immune responses. The presentation of COVID-19 as severe respiratory distress leading to gastrointestinal tract involvement could be mitigated through probiotics administration which beneficially modulates the microbiota and immune responses with an attendant reduction in morbidities, hence curtailing the COVID-19 pandemic.
尽管采用和使用了不同的感染预防和控制措施，冠状病毒病（COVID-19）大流行仍在继续，全球发病率和死亡率不断上升。由于缺乏针对 COVID-19 的特定治疗干预措施，因此需要使用非传统的有效替代品。最近，益生菌已被证明可通过竞争性排斥或拮抗病原体、调节宿主-微生物群、分泌抗菌化合物和刺激免疫反应来减轻许多健康挑战，包括动物和人类传染病。COVID-19 表现为严重的呼吸窘迫，导致胃肠道受累，可以通过益生菌治疗来缓解，益生菌治疗可以有益地调节微生物群和免疫反应，从而降低发病率，从而遏制 COVID-19 大流行。
