Owen M J, Lewis S W, Murray R M
Genetics Section, Institute of Psychiatry, London.
Psychol Med. 1988 May;18(2):331-9. doi: 10.1017/s003329170000787x.
All patients aged 16-50 years who had been discharged from the Maudsley Hospital over a 4-year period with a diagnosis of schizophrenia were ascertained retrospectively. Case records were rated blindly for a history of obstetric complications (OCs). Sixty-one patients who satisfied the RDC for schizophrenia had undergone CT scanning. Those with a definite history of OCs presented at an earlier age. In this group widening of cortical sulci and fissures was more strongly correlated with VBR than in subjects without OCs. Moreover, large VBRs when accompanied by widened cortical sulci and fissures occurred more commonly in subjects with OCs than in those without. These results support the hypothesis that OCs, or a factor associated with them, lead to brain damage of aetiological significance in some cases of schizophrenia.
对所有年龄在16至50岁之间、在4年期间从莫兹利医院出院且诊断为精神分裂症的患者进行了回顾性研究。对病例记录进行盲法评分，以确定产科并发症（OCs）史。61名符合精神分裂症研究诊断标准（RDC）的患者接受了CT扫描。有明确OCs病史的患者发病年龄较早。在这组患者中，皮质沟和脑裂增宽与脑体积比（VBR）的相关性比无OCs的受试者更强。此外，伴有皮质沟和脑裂增宽的大VBR在有OCs的受试者中比在无OCs的受试者中更常见。这些结果支持了以下假设：在某些精神分裂症病例中，OCs或与之相关的一个因素会导致具有病因学意义的脑损伤。
