Nimgaonkar V L, Wessely S, Tune L E, Murray R M
Institute of Psychiatry, London and Phipps Clinic, Johns Hopkins Medical School, Baltimore.
Psychol Med. 1988 Aug;18(3):583-92. doi: 10.1017/s0033291700008266.
A prospective study of antipsychotic drug treatment showed no difference in response between schizophrenic in-patients with or without a familial predisposition to the illness (N = 53). All patients received at least 600 mg chlorpromazine equivalents antipsychotic medication for 6 weeks. Ventricle brain ratios, ratings of cortical sulcal widening and a history of obstetric complications also failed to account for the variability, but early age of onset was associated with unsatisfactory response.
一项关于抗精神病药物治疗的前瞻性研究表明，有或没有该疾病家族易感性的精神分裂症住院患者在反应上没有差异（N = 53）。所有患者接受了至少600毫克氯丙嗪等效剂量的抗精神病药物治疗，为期6周。脑室脑比率、皮质沟增宽评分以及产科并发症史也无法解释这种变异性，但发病年龄早与反应不佳有关。
