Akbari Kordkheyli Vahid, Amir Mishan Mohammad, Khonakdar Tarsi Abbas, Mahrooz Abdolkarim, Rezaei Kanavi Mozhgan, Hafezi-Moghadam Ali, Bagheri Abouzar
Department of Clinical Biochemistry and Medical Genetics, Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Ocular Tissue Engineering Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iran J Basic Med Sci. 2021 Mar;24(3):267-279. doi: 10.22038/ijbms.2021.52164.11807.
Diabetic retinopathy (DR) is ocular microvascular complications of diabetes mellitus. Along with the increasing prevalence of diabetes worldwide, DR has come into the major cause of human blindness. Several studies have demonstrated the important roles of the expression alteration in the proteins contributed to vascular dysfunction during DR, especially vascular endothelial growth factor (VEGF). However, there is a need for further mechanistic research in this context to design new therapeutic and diagnostic programs. MicroRNAs (miRNAs, miRs) have been introduced as key controllers of gene expression in a variety of biological processes including differentiation, proliferation, and metabolism. Altered expression of miRNAs during DR development indicates a close relationship between these regulatory molecules and DR through regulating gene expressions. This review discusses and updates the functions of miRNA-dependent pathways and key roles of VEGF in the DR, which may increase our understanding and ability to target these small but important molecules to efficiently improve therapeutic and diagnostic approaches.
糖尿病视网膜病变（DR）是糖尿病的眼部微血管并发症。随着全球糖尿病患病率的不断上升，DR已成为人类失明的主要原因。多项研究表明，在DR期间，蛋白质表达改变在导致血管功能障碍中发挥重要作用，尤其是血管内皮生长因子（VEGF）。然而，在此背景下仍需要进一步开展机制研究，以设计新的治疗和诊断方案。微小RNA（miRNA，miR）已被视为多种生物学过程（包括分化、增殖和代谢）中基因表达的关键调控因子。DR发展过程中miRNA表达的改变表明，这些调控分子与DR之间通过调节基因表达存在密切关系。本综述讨论并更新了miRNA依赖性途径的功能以及VEGF在DR中的关键作用，这可能会增进我们对这些虽小但重要的分子的理解，并提高我们针对它们进行靶向治疗以有效改进治疗和诊断方法的能力。
