Khazeei Tabari Mohammad Amin, Mirjalili Razie, Khoshhal Hooman, Shokouh Elahe, Khandan Mohanna, Hasheminasabgorji Elham, Hafezi-Moghadam Ali, Bagheri Abouzar
Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
USERN Office, Mazandaran University of Medical Sciences, Sari, Iran.
Evid Based Complement Alternat Med. 2022 Mar 9;2022:4708527. doi: 10.1155/2022/4708527. eCollection 2022.
. Diabetes mellitus (DM), hyperglycemia, and hypertension can result in diabetic retinopathy (DR), which is a major cause of blindness on a global scale. Development of DR is associated with decreased endothelial cells, increased basal membrane thickness, permeation of the retinal blood barrier, and neovascularization in patients. The purpose of the present review is to provide an overview of the findings regarding applications of phytochemicals for DR treatment and could be a beneficial resource for further clinical studies and also a basis for pharmaceutical purposes for drug design. . A narrative literature review was performed from electronic databases including Web of Science, PubMed, and Scopus to analyze the effects of different phytochemicals to prevent or treat oxidation, angiogenesis, and inflammation in diabetic retinopathy. The inclusion criteria were original studies, which included the effects of different phytochemicals on diabetic retinopathy. The exclusion criteria included studies other than original articles, studies which assessed the effects of phytochemicals on nondiabetic retinopathy, and studies which used phytochemical-rich extracts. . Studies have shown that increased levels of inflammatory cytokines, angiogenic, and oxidative stress factors are involved in the progression and pathogenesis of DR. Therefore, phytochemicals with their anti-inflammatory, antiangiogenic, and antioxidant properties can prevent DR progression and retinal damage through various cellular mechanisms. It is also shown that some phytochemicals can simultaneously affect the inflammation, oxidation, and angiogenesis in DR.
糖尿病（DM）、高血糖和高血压可导致糖尿病视网膜病变（DR），这是全球范围内失明的主要原因。DR的发展与患者内皮细胞减少、基底膜厚度增加、视网膜血屏障通透性增加和新生血管形成有关。本综述的目的是概述植物化学物质在DR治疗中的应用研究结果，这可能为进一步的临床研究提供有益资源，也是药物设计的药学依据。 从包括科学网、PubMed和Scopus在内的电子数据库中进行叙述性文献综述，以分析不同植物化学物质对糖尿病视网膜病变中氧化、血管生成和炎症的预防或治疗作用。纳入标准为原创研究，包括不同植物化学物质对糖尿病视网膜病变的影响。排除标准包括非原创文章的研究、评估植物化学物质对非糖尿病性视网膜病变影响的研究以及使用富含植物化学物质提取物的研究。 研究表明，炎症细胞因子、血管生成和氧化应激因子水平升高参与了DR的进展和发病机制。因此，具有抗炎、抗血管生成和抗氧化特性的植物化学物质可以通过各种细胞机制预防DR进展和视网膜损伤。还表明，一些植物化学物质可以同时影响DR中的炎症、氧化和血管生成。
