Arjmand Babak, Rezaei Tavirani Mostafa, Razzaghi Mohammadreza, Rostami-Nejad Mohammad, Hamdieh Mostafa, Nikzamir Abdolrahim
Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Lasers Med Sci. 2020 Fall;11(Suppl 1):S30-S36. doi: 10.34172/jlms.2020.S5. Epub 2020 Dec 30.
Although the application of ultraviolet B (UVB) in phototherapy of human skin is a common therapeutic method, it is known as a risk factor for skin cancer. This study aims to assess the role of differentially expressed genes (DEGs) to find the critical one that is mainly responsible for skin protection against UVB radiation. The gene expression profiles of irradiated mice by UVB that issued skin protection against exposure are extracted from Gene Expression Omnibus (GEO) and analyzed by GEO2R. The significant DEGs are assessed via gene ontology (GO) analysis and the critical individuals are investigated via action mapping. Thirty-eight significant DEGs that provide skin resistance against UVB irradiation were determined. Among the query DEGs, 26 individuals were related to 43 biological terms. Flt4, F3, Tspan6, Cblb, and Itgb6 were highlighted as the critical DEGs to promote skin protection against UVB irradiation. The finding indicates that Flt4 is the key DEG that is mainly responsible for protecting skin from UVB exposure.
尽管紫外线B（UVB）在人类皮肤光疗中的应用是一种常见的治疗方法，但它被认为是皮肤癌的一个风险因素。本研究旨在评估差异表达基因（DEG）的作用，以找到主要负责皮肤抵御UVB辐射的关键基因。从基因表达综合数据库（GEO）中提取对UVB照射具有皮肤保护作用的UVB照射小鼠的基因表达谱，并通过GEO2R进行分析。通过基因本体（GO）分析评估显著差异表达基因，并通过作用图谱研究关键个体。确定了38个提供皮肤对UVB辐射抗性的显著差异表达基因。在查询的差异表达基因中，26个个体与43个生物学术语相关。Flt4、F3、Tspan6、Cblb和Itgb6被突出显示为促进皮肤抵御UVB辐射的关键差异表达基因。该发现表明Flt4是主要负责保护皮肤免受UVB照射的关键差异表达基因。
