Hajjarian Zeinab, Toussaint Jimmy D, Guerrero J Luis, Nadkarni Seemantini K
Wellman Center for Photomedicine, Massachusetts General Hospital & Harvard Medical School, Boston, MA 02114, USA.
Authors contributed equally to the manuscript.
Biomed Opt Express. 2021 Mar 16;12(4):2064-2078. doi: 10.1364/BOE.418939. eCollection 2021 Apr 1.
The ability to evaluate the viscoelastic properties of coronary arteries is crucial for identifying mechanically unstable atherosclerotic plaques. Here, we demonstrate for the first time in living swine, the capability of intravascular laser speckle imaging (ILSI) to measure an index of coronary plaque viscoelasticity, τ, using a human coronary to swine xenograft model. Cardiac motion effects are evaluated by comparing the EKG-non-gated , and EKG-gated among different plaque types. Results show that both and are significantly lower in necrotic-core plaques compared with stable lesions. Discrete-point pullback measurements demonstrate the capability of ILSI for rapid mechanical characterization of coronary segments under physiological conditions, .
评估冠状动脉粘弹性特性的能力对于识别机械不稳定的动脉粥样硬化斑块至关重要。在此，我们首次在活体猪中，利用人冠状动脉到猪的异种移植模型，展示了血管内激光散斑成像（ILSI）测量冠状动脉斑块粘弹性指数τ的能力。通过比较不同斑块类型之间的心电图非门控和心电图门控情况来评估心脏运动影响。结果表明，与稳定病变相比，坏死核心斑块中的两者均显著降低。离散点回撤测量证明了ILSI在生理条件下对冠状动脉节段进行快速机械表征的能力。
