Tutt S M, McGregor K H, Hainsworth R
Department of Cardiovascular Studies, University of Leeds.
Q J Exp Physiol. 1988 May;73(3):425-37. doi: 10.1113/expphysiol.1988.sp003158.
In dogs anaesthetized with chloralose, changes in left ventricular systolic pressure were induced using a preparation in which the pressure changes did not distend the aortic arch and in which left atrial and carotid sinus pressures were held constant. The systemic circulation was perfused at constant flow and drained from the venae cavae at constant pressure. An increase in left ventricular systolic pressure caused reflex dilatation of systemic resistance and capacitance vessels as indicated by decreases in arterial perfusion pressure and venous outflow. Responses were obtained when ventricular systolic pressure changed between 16 and 28 kPa (120-210 mHg). Responses to changes in ventricular pressure were reduced when the carotid sinuses were perfused at high pressures. These results indicate that changes in pressure in the left ventricle result in reflex changes in vascular resistance and capacitance and that responses are obtained to changes in ventricular pressure over a physiological range.
在用氯醛糖麻醉的犬中，使用一种制备方法诱导左心室收缩压的变化，该方法中压力变化不会使主动脉弓扩张，且左心房和颈动脉窦压力保持恒定。以恒定流量灌注体循环，并在恒定压力下从腔静脉引流。左心室收缩压升高导致全身阻力血管和容量血管反射性扩张，表现为动脉灌注压和静脉流出量降低。当心室收缩压在16至28 kPa（120 - 210 mmHg）之间变化时可获得反应。当颈动脉窦在高压下灌注时，对心室压力变化的反应减弱。这些结果表明，左心室内压力的变化会导致血管阻力和容量的反射性变化，并且在生理范围内对心室压力变化可获得反应。
