Vukasovic J L, Tutt S M, Crisp A J, Hainsworth R
Department of Cardiovascular Studies, University of Leeds.
Q J Exp Physiol. 1989 Sep;74(5):735-46. doi: 10.1113/expphysiol.1989.sp003325.
The aim of this study was to determine whether the degree of stimulation of left ventricular receptors influenced the sensitivity of the carotid sinus baroreceptor reflex. In anaesthetized dogs, the stimulus to left ventricular receptors was changed by changing aortic root and hence ventricular systolic pressure, using a preparation in which the applied pressure did not distend the aortic arch and in which left atrial pressure was controlled. A large step increase in either carotid or left ventricular pressure resulted in vasodilatation both in a perfused hindlimb and in the remainder of the systemic circulation and resulted in a reduction in the response to a change in pressure in the other area. The stimulus-response curves, relating limb and systemic perfusion pressures to small step changes in carotid sinus pressure, were displaced downwards at high left ventricular pressures. However, the curves remained parallel indicating the absence of an interactive effect. These results indicate that the vascular responses to changes in carotid and ventricular pressures show simple additive summation.
本研究的目的是确定左心室感受器的刺激程度是否会影响颈动脉窦压力感受器反射的敏感性。在麻醉犬中，通过改变主动脉根部从而改变心室收缩压来改变对左心室感受器的刺激，采用的制备方法是施加的压力不会使主动脉弓扩张且左心房压力得到控制。颈动脉或左心室压力的大幅阶跃增加会导致灌注后肢和全身循环其余部分的血管舒张，并导致对另一区域压力变化的反应降低。将肢体和全身灌注压力与颈动脉窦压力的小阶跃变化相关的刺激-反应曲线在高左心室压力下向下移位。然而，这些曲线保持平行，表明不存在交互作用。这些结果表明，对颈动脉和心室压力变化的血管反应表现为简单的相加总和。
