Ali Amir, Gupta Praveena K
Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, USA.
Cureus. 2021 Apr 12;13(4):e14434. doi: 10.7759/cureus.14434.
Cannabinoid (CBD) products have gained popularity since their legalization in 2018, causing a plethora of unregulated CBD products to be sold in the United States. These products are available in various combinations for topical and oral consumption, claiming credit for potentially improving various diseases. In this report, we present a newfound case reporting a shift in refraction that may be associated with the regular use of CBD oil supplements. A 57-year-old woman with a history of diabetes mellitus type 2, hyperlipidemia, obstructive sleep apnea, with no change in medications, diet, or lifestyle was found to have a hyperopic shift in vision with the recent daily addition of CBD oil intake. This case report highlights the possible association of CBD oil and vision changes after regular consumption of CBD oil in an otherwise stable patient. Further study is required to understand the mechanisms of CBD oil-associated shift in refractive error. Because the patient is diabetic and the refraction shift was hyperopic, other etiologies, such as un-noted lenticular change, cannot be ruled out. CBD products are unregulated and marketed in many mixed forms, and thus can cause unforeseen effects on susceptible individuals. This warrants Food and Drug Administration (FDA) regulation of such products and extensive research before considering them for therapeutic usage.
自2018年大麻二酚（CBD）产品合法化以来，其广受欢迎，导致美国市场上出现大量未经监管的CBD产品。这些产品有多种组合形式，可用于局部涂抹和口服，并宣称可能对多种疾病有改善作用。在本报告中，我们呈现了一个新发现的病例，该病例报告了屈光变化，这可能与经常使用CBD油补充剂有关。一名57岁女性，有2型糖尿病、高脂血症、阻塞性睡眠呼吸暂停病史，在药物、饮食或生活方式均无改变的情况下，最近每日摄入CBD油后出现了远视性视力变化。本病例报告强调了在一名病情原本稳定的患者中，经常食用CBD油后可能与视力变化存在关联。需要进一步研究以了解CBD油相关的屈光不正变化机制。由于该患者患有糖尿病且屈光变化为远视，其他病因，如未被注意到的晶状体变化，不能排除。CBD产品未经监管且以多种混合形式销售，因此可能对易感个体产生不可预见的影响。这就需要美国食品药品监督管理局（FDA）对此类产品进行监管，并在考虑将其用于治疗用途之前进行广泛研究。
