Morimura Ayumi, Hamaguchi Shigeto, Akeda Yukihiro, Tomono Kazunori
Department of Infection Control and Prevention, Osaka University Graduate School of Medicine, Osaka, Japan.
Division of Infection Control and Prevention, Osaka University Hospital, Osaka, Japan.
Front Cell Infect Microbiol. 2021 Apr 28;11:639450. doi: 10.3389/fcimb.2021.639450. eCollection 2021.
(also called pneumococcus) is not only a commensal that frequently colonizes the human upper respiratory tract but also a pathogen that causes pneumonia, sepsis, and meningitis. The mechanism of pneumococcal infection has been extensively studied, but the process of transmission has not been fully elucidated because of the lack of tractable animal models. Novel animal models of transmission have enabled further progress in investigating pneumococcal transmission mechanisms including the processes such as pneumococcal shedding, survival in the external environment, and adherence to the nasopharynx of a new host. Herein, we present a review on these animal models, recent research findings about pneumococcal transmission, and factors influencing the host-pneumococcus interaction.
（也称为肺炎球菌）不仅是一种经常定植于人类上呼吸道的共生菌，也是一种可导致肺炎、败血症和脑膜炎的病原体。肺炎球菌感染的机制已得到广泛研究，但由于缺乏易于处理的动物模型，其传播过程尚未完全阐明。新型传播动物模型在研究肺炎球菌传播机制方面取得了进一步进展，这些机制包括肺炎球菌脱落、在外部环境中的存活以及对新宿主鼻咽部的黏附等过程。在此，我们对这些动物模型、肺炎球菌传播的最新研究发现以及影响宿主-肺炎球菌相互作用的因素进行综述。
