Takeiwa Toshihiko, Ikeda Kazuhiro, Horie-Inoue Kuniko, Inoue Satoshi
Division of Systems Medicine & Gene Therapy, Saitama Medical University, Saitama, Japan.
Department of Systems Aging Science and Medicine, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Front Cell Dev Biol. 2021 Apr 29;9:641963. doi: 10.3389/fcell.2021.641963. eCollection 2021.
Ovarian cancer is a health-threatening malignancy of ovary in female reproductive systems and one of the most common gynecological malignancies worldwide. Due to rare early symptoms, ovarian cancers are often diagnosed at advanced stages and exhibit poor prognosis. Thus, efforts have been paid to develop alternative diagnostic and therapeutic strategies for the disease. Recent studies have presented that some long non-coding RNAs (lncRNAs) play roles in apoptosis of ovarian cancer cells through various mechanisms involved in the regulation of transcription factors, histone modification complexes, miRNAs, and protein stability. Because evasion of apoptosis in cancer cells facilitates to promote tumor progression and therapy resistance, apoptosis regulatory mechanisms of lncRNAs may be promising new targets in ovarian cancer. In this review, we introduce the recent findings in regard to the molecular mechanisms of apoptosis-related lncRNAs in ovarian cancer cells.
卵巢癌是女性生殖系统中一种威胁健康的卵巢恶性肿瘤，也是全球最常见的妇科恶性肿瘤之一。由于早期症状罕见，卵巢癌往往在晚期才被诊断出来，预后较差。因此，人们一直在努力开发针对该疾病的替代诊断和治疗策略。最近的研究表明，一些长链非编码RNA（lncRNAs）通过参与转录因子、组蛋白修饰复合物、微小RNA（miRNAs）和蛋白质稳定性调节的各种机制，在卵巢癌细胞的凋亡中发挥作用。由于癌细胞逃避凋亡有助于促进肿瘤进展和治疗耐药性，lncRNAs的凋亡调节机制可能是卵巢癌中有前景的新靶点。在这篇综述中，我们介绍了关于卵巢癌细胞中与凋亡相关的lncRNAs分子机制的最新研究结果。
