非编码 RNA 在调控线粒体电子传递链和氧化磷酸化中的作用。
Roles of Noncoding RNAs in Regulation of Mitochondrial Electron Transport Chain and Oxidative Phosphorylation.
机构信息
Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Rd., Boston, MA 02115, USA.
Department of Systems Aging Science and Medicine, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi-ku, Tokyo 173-0015, Japan.
出版信息
Int J Mol Sci. 2023 May 28;24(11):9414. doi: 10.3390/ijms24119414.
The mitochondrial electron transport chain (ETC) plays an essential role in energy production by inducing oxidative phosphorylation (OXPHOS) to drive numerous biochemical processes in eukaryotic cells. Disorders of ETC and OXPHOS systems are associated with mitochondria- and metabolism-related diseases, including cancers; thus, a comprehensive understanding of the regulatory mechanisms of ETC and OXPHOS systems is required. Recent studies have indicated that noncoding RNAs (ncRNAs) play key roles in mitochondrial functions; in particular, some ncRNAs have been shown to modulate ETC and OXPHOS systems. In this review, we introduce the emerging roles of ncRNAs, including microRNAs (miRNAs), transfer-RNA-derived fragments (tRFs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs), in the mitochondrial ETC and OXPHOS regulation.
线粒体电子传递链（ETC）通过诱导氧化磷酸化（OXPHOS）在真核细胞中驱动众多生化过程，从而在能量产生中发挥着重要作用。ETC 和 OXPHOS 系统的紊乱与线粒体和代谢相关疾病有关，包括癌症；因此，需要全面了解 ETC 和 OXPHOS 系统的调节机制。最近的研究表明，非编码 RNA（ncRNA）在线粒体功能中发挥着关键作用；特别是，一些 ncRNA 已被证明可以调节 ETC 和 OXPHOS 系统。在这篇综述中，我们介绍了 ncRNA（包括 microRNAs（miRNAs）、转运 RNA 衍生片段（tRFs）、长 ncRNA（lncRNA）和环状 RNA（circRNA））在调节线粒体 ETC 和 OXPHOS 中的新兴作用。
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