Derbyshire Emma J, Calder Philip C
Nutritional Insight, London, United Kingdom.
School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Front Nutr. 2021 Apr 29;8:652410. doi: 10.3389/fnut.2021.652410. eCollection 2021.
Bronchiectasis is a chronic condition in which areas of the bronchial tubes become permanently widened predisposing the lungs to infection. Bronchiectasis is an age-associated disease with the highest prevalence in people older than 75 years. While the prevalence of bronchiectasis is higher in males, disease is more severe in females who have a poorer prognosis. The overall prevalence of the disease is thought to be rising. Its aetiology is multi-faceted, but a compromised immune system is now thought to play a central role in the pathology of this disease. Research has begun to study the role of malnutrition and certain nutrients-vitamin D and zinc-along with the role of the lung microbiome in relation to the management of bronchiectasis. Given this, the present mini review sets out to provide an overview of the state-of-the-art within the field, identify research gaps and pave the way for future developments and research investment within this field.
支气管扩张是一种慢性疾病，其中支气管区域会永久性变宽，使肺部易受感染。支气管扩张是一种与年龄相关的疾病，在75岁以上人群中患病率最高。虽然支气管扩张在男性中的患病率较高，但在预后较差的女性中病情更为严重。据认为，该疾病的总体患病率正在上升。其病因是多方面的，但现在认为免疫系统受损在该疾病的病理过程中起核心作用。研究已开始探讨营养不良和某些营养素（维生素D和锌）的作用，以及肺部微生物群在支气管扩张管理中的作用。鉴于此，本综述旨在概述该领域的最新状况，找出研究空白，并为该领域的未来发展和研究投资铺平道路。
