Clinical and Experimental Endocrinology (CEE), KU Leuven. Campus Gasthuisberg O&N1, Herestraat 49, box 902, 3000 Leuven, Belgium.
Nutrients. 2020 Apr 28;12(5):1248. doi: 10.3390/nu12051248.
Ever since its discovery by Windhaus, the importance of the active metabolite of vitamin D (1,25-dihydroxyvitamin D; 1,25-(OH)2D) has been ever expanding. In this review, the attention is shifted towards the importance of the extra-skeletal effects of vitamin D, with special emphasis on the immune system. The first hint of the significant role of vitamin D on the immune system was made by the discovery of the presence of the vitamin D receptor on almost all cells of the immune system. In vitro, the overwhelming effect of supra-physiological doses of vitamin D on the individual components of the immune system is very clear. Despite these promising pre-clinical results, the translation of the in vitro observations to solid clinical effects has mostly failed. Nevertheless, the evidence of a link between vitamin D deficiency and adverse outcomes is overwhelming and clearly points towards avoidance of vitamin D deficiency especially in early life.
自从 Windhaus 发现维生素 D 的活性代谢物（1,25-二羟维生素 D；1,25-(OH)2D）以来，其重要性一直在不断扩大。在这篇综述中，我们将注意力转向维生素 D 的骨骼外作用的重要性，特别强调免疫系统。维生素 D 对免疫系统的重要作用的第一个迹象是在几乎所有免疫系统细胞上发现了维生素 D 受体。在体外，超生理剂量的维生素 D 对免疫系统各个组成部分的压倒性影响非常明显。尽管这些有前景的临床前结果，但将体外观察结果转化为坚实的临床效果在大多数情况下都失败了。然而，维生素 D 缺乏与不良后果之间的联系的证据是压倒性的，这清楚地表明特别是在生命早期要避免维生素 D 缺乏。
