Morris Elizabeth M, Kitts-Morgan Susanna E, Spangler Dawn M, Gebert Jessica, Vanzant Eric S, McLeod Kyle R, Harmon David L
Department of Animal and Food Sciences, University of Kentucky, Lexington, KY, United States.
College of Veterinary Medicine, Lincoln Memorial University, Harrogate, TN, United States.
Front Vet Sci. 2021 Apr 29;8:645667. doi: 10.3389/fvets.2021.645667. eCollection 2021.
Growing public interest in the use of cannabidiol (CBD) for companion animals has amplified the need to elucidate potential impacts. The purpose of this investigation was to determine the influence of CBD on the daily activity of adult dogs. Twenty-four dogs (18.0 ± 3.4 kg, 9 months-4 years old) of various mixed breeds were utilized in a randomized complete block design with treatments targeted at 0 and 2.5 mg (LOW) and at 5.0 mg (HIGH) CBD/kg body weight (BW) per day split between two treats administered after twice-daily exercise (0700-0900 and 1,700-1,900 h). Four hours each day [1,000-1,200 h (a.m.) and 1,330-1,530 h (p.m.)] were designated as times when no people entered the kennels, with 2 h designated as Quiet time and the other 2 h as Music time, when calming music played over speakers. Quiet and Music sessions were randomly allotted to daily a.m. or p.m. times. Activity monitors were fitted to dogs' collars for continuous collection of activity data. Data were collected over a 14-day baseline period to establish the activity patterns and block dogs by activity level (high or low) before randomly assigning dogs within each block to treatments. After 7 days of treatment acclimation, activity data were collected for 14 days. Data were examined for differences using the MIXED procedure in SAS including effects of treatment, day, session (Quiet or Music), time of day (a.m. or p.m.), and accompanying interactions. CBD (LOW and HIGH) did not alter the total daily activity points ( = 0.985) or activity duration ( = 0.882). CBD tended ( = 0.071) to reduce total daily scratching compared with the control. Dogs were more active in p.m. sessions than in a.m. sessions ( < 0.001). During the p.m. session, dogs receiving HIGH tended ( = 0.091) to be less active than the control (CON). During the a.m. and p.m. sessions, CBD reduced scratching compared with CON ( = 0.030). CBD did not affect the activity duration during exercise periods ( = 0.143). These results indicate that, when supplemented with up to 4.5 mg CBD/kg BW/day, CBD does not impact the daily activity of adult dogs, but may exert an antipruritic effect.
公众对将大麻二酚（CBD）用于伴侣动物的兴趣日益浓厚，这凸显了阐明其潜在影响的必要性。本研究的目的是确定CBD对成年犬日常活动的影响。采用随机完全区组设计，选用24只不同混种犬（体重18.0±3.4千克，年龄9个月至4岁），治疗方案为每天每千克体重（BW）给予0毫克和2.5毫克（低剂量）以及5.0毫克（高剂量）的CBD，分两次在每日运动后（07:00 - 09:00和17:00 - 19:00）给予两种零食。每天有4个小时[10:00 - 12:00（上午）和13:30 - 15:30（下午）]被指定为无人进入犬舍的时间，其中2小时为安静时间，另外2小时为音乐时间，期间通过扬声器播放舒缓的音乐。安静和音乐时段随机分配到每日上午或下午的时间。在犬的项圈上安装活动监测器，以持续收集活动数据。在14天的基线期收集数据，以建立活动模式，并根据活动水平（高或低）对犬进行分组，然后在每个组内随机将犬分配到不同治疗组。经过7天的治疗适应期后，收集14天的活动数据。使用SAS中的混合程序对数据进行差异检验，包括治疗、天数、时段（安静或音乐）、一天中的时间（上午或下午）以及相关交互作用的影响。CBD（低剂量和高剂量）并未改变每日总活动点数（P = 0.985）或活动时长（P = 0.882）。与对照组相比，CBD有降低每日总抓挠次数的趋势（P = 0.071）。犬在下午时段比上午时段更活跃（P < 0.001）。在下午时段，接受高剂量CBD的犬比对照组（CON）活跃度有降低的趋势（P = 0.091）。在上午和下午时段，与对照组相比，CBD减少了抓挠次数（P = 0.030）。CBD对运动期间的活动时长没有影响（P = 0.143）。这些结果表明，当每天补充高达4.5毫克/千克体重的CBD时，CBD不会影响成年犬的日常活动，但可能具有止痒作用。
