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miRNA-373 与 HIF-1、MMP-9、VEGF 在新生儿缺氧缺血性脑病发病中的相关性的实验研究。

Experimental Study on the Correlation between miRNA-373 and HIF-1, MMP-9, and VEGF in the Development of HIE.

机构信息

Department of Biochemistry and Molecular Biology, Jiamusi University School of Basic Medical Sciences, Jiamusi, China.

AnKang University, School of Medicine, Ankang, Shanxi Province 725000, China.

出版信息

Biomed Res Int. 2021 May 3;2021:5553486. doi: 10.1155/2021/5553486. eCollection 2021.

DOI:10.1155/2021/5553486
PMID:33997006
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8112928/
Abstract

INTRODUCTION

Microribonucleic acids (miRNAs) have short (approximately 18 to 25) nucleotides and are evolutionarily conserved and endogenously expressed RNAs belonging to a family of noncoding RNA molecules. miRNA-373 regulates cell proliferation, migration, apoptosis, invasion, and repairing damaged DNA after hypoxia stress. Neonatal hypoxic-ischemic encephalopathy (HIE) refers to perinatal asphyxia caused by partial or complete hypoxia, reduced or suspended cerebral blood flow, and fetal or neonatal brain damage. We aim to investigate the relationship between miRNA-373 and HIF-1, between miRNA-373 MMP-9, and between miRNA-373 VEGF in the occurrence and development of HIE.

METHODS

Human (children) samples were divided into four groups ( = 15 in each group) according to HIE severity. The patient group was divided into middle, moderate, and severe HIE groups. The control group included healthy children or children with nonneurological diseases. The expressions of miRNA-373, HIF-1, MMP-9, and VEGF were assayed in the serum samples.

RESULTS

Our study showed a strong relationship between miRNA-373 and HIF-1, between miRNA-373 and MMP-9, and between miRNA-373 and VEGF. The expression levels of miRNA-373, HIF-1, MMP-9, and VEGF in the HIE groups were much higher than those of the control group.

CONCLUSION

The increased change in miRNA-373 expression has a certain diagnostic significance on neonatal HIE. In the occurrence and development of HIE, miRNA-373 is positively correlated with HIF-1, MMP-9, and VEGF.

摘要

简介

微小 RNA（miRNAs）具有约 18 到 25 个核苷酸，是进化上保守的内源性表达 RNA，属于非编码 RNA 分子家族。miRNA-373 调节细胞增殖、迁移、凋亡、侵袭和修复缺氧应激后的受损 DNA。新生儿缺氧缺血性脑病（HIE）是指围产期由于部分或完全缺氧、脑血流量减少或暂停、胎儿或新生儿脑损伤引起的窒息。我们旨在研究 miRNA-373 与 HIF-1 之间、miRNA-373 与 MMP-9 之间以及 miRNA-373 与 VEGF 之间的关系，探讨它们在 HIE 发生和发展中的作用。

方法

根据 HIE 严重程度，将人（儿童）样本分为四组（每组=15）。患者组分为中、中重度和重度 HIE 组。对照组包括健康儿童或非神经疾病儿童。检测血清样本中 miRNA-373、HIF-1、MMP-9 和 VEGF 的表达。

结果

我们的研究表明 miRNA-373 与 HIF-1 之间、miRNA-373 与 MMP-9 之间以及 miRNA-373 与 VEGF 之间存在很强的相关性。HIE 组的 miRNA-373、HIF-1、MMP-9 和 VEGF 的表达水平明显高于对照组。

结论

miRNA-373 表达水平的升高变化对新生儿 HIE 具有一定的诊断意义。在 HIE 的发生和发展过程中，miRNA-373 与 HIF-1、MMP-9 和 VEGF 呈正相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f44/8112928/2624a4efc9ed/BMRI2021-5553486.007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f44/8112928/1c32fc497300/BMRI2021-5553486.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f44/8112928/2624a4efc9ed/BMRI2021-5553486.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f44/8112928/44dbe1480f26/BMRI2021-5553486.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f44/8112928/e472221b5ae5/BMRI2021-5553486.002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f44/8112928/1c32fc497300/BMRI2021-5553486.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f44/8112928/2624a4efc9ed/BMRI2021-5553486.007.jpg

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