Zhang Junhui, Han Jian, Li Lingfei, Zhang Qiong, Feng Yanhai, Jiang Youzhao, Deng Fang, Zhang Yuping, Wu Qinan, Chen Bing, Hu Jiongyu
Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, PR China.
State Key Laboratory of Trauma, Burns and Combined Injury, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, PR China.
Genes Dis. 2020 Mar 21;8(3):272-278. doi: 10.1016/j.gendis.2020.03.006. eCollection 2021 May.
Inwardly rectifying potassium (Kir) channels make it easier for K to enter into a cell and subsequently regulate cellular biological functions. Kir5.1 (encoded by ) alone can form a homotetramer and can form heterotetramers with Kir4.1 (encoded by ) or Kir4.2 (encoded by ). In most cases, homomeric Kir5.1 is non-functional, while heteromeric Kir5.1 on the cell membrane contributes to the inward flow of K ions, which can be regulated by intracellular pH and a variety of signaling mechanisms. In the form of a heterotetramer, Kir5.1 regulates Kir4.1/4.2 activity and is involved in the maintenance of nephron function. Actually, homomeric Kir5.1 may also play a very important role in diseases, including in the ventilatory response to hypoxia and hypercapnia, hearing impairment, cardiovascular disease and cancer. With an increase in the number of studies into the roles of Kir channels, researchers are paying more attention to the pathophysiological functions of Kir5.1. This minireview provides an overview regarding these Kir5.1 roles.
内向整流钾（Kir）通道使钾更容易进入细胞并随后调节细胞生物学功能。单独的Kir5.1（由 编码）可以形成同四聚体，并且可以与Kir4.1（由 编码）或Kir4.2（由 编码）形成异四聚体。在大多数情况下，同源Kir5.1无功能，而细胞膜上的异源Kir5.1有助于钾离子的内向流动，其可由细胞内pH和多种信号传导机制调节。以异四聚体的形式，Kir5.1调节Kir4.1/4.2活性并参与肾单位功能的维持。实际上，同源Kir5.1在疾病中也可能起非常重要的作用，包括在对缺氧和高碳酸血症的通气反应、听力障碍、心血管疾病和癌症中。随着对Kir通道作用研究数量的增加，研究人员越来越关注Kir5.1的病理生理功能。本综述提供了关于这些Kir5.1作用的概述。
