Caverni Camila Naegeli, da Costa Aline Turbino, Simioni Caio Grava, Fukue Rosemeire Rocha, Tengan Celia Harumi, Villa Thais Rodrigues
Department of Neurology & Neurosurgery, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil.
Heliyon. 2021 Apr 25;7(4):e06865. doi: 10.1016/j.heliyon.2021.e06865. eCollection 2021 Apr.
Migraine is a primary headache with high prevalence in the general population but is considered a disabling medical condition. It is suggested that obesity is a risk factor for chronic migraine. Thus treatment with drugs, such as topiramate, which reduces pain and weight, is ideal for obese patients with migraine. The aim of this study was to evaluate the effects of topiramate on body composition in patients with chronic migraine and to verify whether these effects could be related to nutritional status. We studied 26 female patients with age ranging from 18 to 45 years with prophylactic treatment with topiramate (50 mg/day) for three months. Body composition indexes (body mass index, BMI; body fat, BF; fat-free mass, FFM) were obtained through anthropometric assessment. After treatment, topiramate reduced BMI (0,82 kg/m) and in BF (3.3 %), but increased FFM (1.1 kg). When considering nutritional status, FFM was increased only in obese patients. In conclusion, our main finding is that besides the reduction in BMI and BF, topiramate led to an increase in FFM in overweight and obese patients. Our results open new perspectives for future studies on the relationship between body composition and migraine, indicating that more studies on this body compartment are needed, especially in patients with chronic migraine.
偏头痛是一种在普通人群中患病率较高的原发性头痛，但被认为是一种致残性疾病。有人认为肥胖是慢性偏头痛的一个危险因素。因此，使用托吡酯等既能减轻疼痛又能减轻体重的药物进行治疗，对肥胖的偏头痛患者来说是理想的选择。本研究的目的是评估托吡酯对慢性偏头痛患者身体成分的影响，并验证这些影响是否与营养状况有关。我们研究了26名年龄在18至45岁之间的女性患者，她们接受了为期三个月的托吡酯预防性治疗（50毫克/天）。通过人体测量评估获得身体成分指标（体重指数、BMI；体脂、BF；去脂体重、FFM）。治疗后，托吡酯降低了BMI（0.82千克/平方米）和BF（3.3%），但增加了FFM（1.1千克）。考虑到营养状况，只有肥胖患者的FFM增加。总之，我们的主要发现是，除了降低BMI和BF外，托吡酯还导致超重和肥胖患者的FFM增加。我们的结果为未来关于身体成分与偏头痛之间关系的研究开辟了新的视角，表明需要对这个身体部分进行更多的研究，特别是在慢性偏头痛患者中。
