1 Department of Neurology, Hospital Clínico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain.
2 Clinical Neurosciences Research Laboratory, University of Santiago de Compostela, Santiago de Compostela, Spain.
Cephalalgia. 2018 Apr;38(5):904-911. doi: 10.1177/0333102417720213. Epub 2017 Jul 5.
Background Obesity is a risk factor for migraine and headache chronification. Adipocytokines may be involved in this correlation. Objective To relate serum adipocytokine levels to clinical and biochemical parameters associated with migraine. Methods We measured levels of leptin, adiponectin and other inflammatory (interleukin 6, interleukin 10, tumor necrosis factor α, high sensitivity C-reactive protein) and endothelial (pentraxin 3, soluble TNF-like weak inducer of apoptosis) molecules potentially related to migraine pathophysiology in a group of migraine patients (IHS 2013) and healthy controls. Results One hundred and eleven patients (mean age 39.7 years, 93% female) and 24 healthy controls (mean age 35.9 years, 90% female) were included. Fifty-six patients were diagnosed with episodic migraine (mean age 35.1 years, 98.2% female) and 55 patients with chronic migraine (mean age 44.4 years, 89.5% female). Leptin serum levels (15.2 ng/mL, SD = 10.5 vs . 3.1 ng/mL, SD = 0.9; p < 0.001) and adiponectin serum levels (72.3 µg/mL, SD = 38.5 vs . 37.7 µg/mL, SD = 16.9; p < 0.001) were significantly increased in migraine patients. Leptin serum levels (15.5 ng/mL, SD = 9.7 vs . 10.8 ng/mL, SD = 6.0; p < 0.001) and adiponectin serum levels (65.8 µg/mL, SD = 42.9 vs . 33.2 µg/mL, SD = 31.0; p < 0.001) were significantly higher in chronic compared to episodic migraine patients. We found a positive correlation between leptin levels and inflammatory biomarkers: IL6 (r = 0.498; p < 0.001), TNF-α (r = 0.389; p < 0.001), and hs-CRP (r = 0.422; p < 0.001). Conclusions Leptin and adiponectin are increased in migraineurs. There is a correlation between adipocytokine levels and other inflammation-related molecules. This suggests a potential role of adipocytokines in migraine pathophysiology and chronification.
肥胖是偏头痛和头痛慢性化的一个危险因素。脂肪细胞因子可能与这种相关性有关。目的：将血清脂肪细胞因子水平与偏头痛相关的临床和生化参数相关联。方法：我们测量了一组偏头痛患者（国际头痛协会 2013 年分类）和健康对照组中与偏头痛病理生理学相关的潜在炎症（白细胞介素 6、白细胞介素 10、肿瘤坏死因子-α、高敏 C 反应蛋白）和内皮（五聚素 3、可溶性肿瘤坏死因子样弱凋亡诱导物）分子的瘦素、脂联素和其他炎症（白细胞介素 6、白细胞介素 10、肿瘤坏死因子-α、高敏 C 反应蛋白）和内皮（五聚素 3、可溶性肿瘤坏死因子样弱凋亡诱导物）分子的水平。结果：共纳入 111 例偏头痛患者（平均年龄 39.7 岁，93%为女性）和 24 例健康对照组（平均年龄 35.9 岁，90%为女性）。56 例患者被诊断为发作性偏头痛（平均年龄 35.1 岁，98.2%为女性），55 例患者为慢性偏头痛（平均年龄 44.4 岁，89.5%为女性）。偏头痛患者的血清瘦素水平（15.2ng/ml，SD=10.5vs.3.1ng/ml，SD=0.9；p<0.001）和脂联素水平（72.3μg/ml，SD=38.5vs.37.7μg/ml，SD=16.9；p<0.001）明显升高。与发作性偏头痛相比，慢性偏头痛患者的血清瘦素水平（15.5ng/ml，SD=9.7vs.10.8ng/ml，SD=6.0；p<0.001）和脂联素水平（65.8μg/ml，SD=42.9vs.33.2μg/ml，SD=31.0；p<0.001）明显更高。我们发现瘦素水平与炎症生物标志物之间存在正相关：IL6（r=0.498；p<0.001）、TNF-α（r=0.389；p<0.001）和 hs-CRP（r=0.422；p<0.001）。结论：偏头痛患者的瘦素和脂联素水平升高。脂肪细胞因子水平与其他炎症相关分子之间存在相关性。这表明脂肪细胞因子在偏头痛的病理生理学和慢性化中可能发挥作用。
