La-Up Aroon, Saengow Udomsak, Aramrattana Apinun
School of Public Health, Walailak University, 222 Thai Buri, Tha Sala, Nakhon Si Thammarat 80160, Thailand.
School of Medicine, Walailak University, 222 Thai Buri, Tha Sala, Nakhon Si Thammarat 80160, Thailand.
Heliyon. 2021 Apr 28;7(4):e06931. doi: 10.1016/j.heliyon.2021.e06931. eCollection 2021 Apr.
The present study aims to examine the association between Kratom use and serum lipid level.
This study compared the serum lipid profile of Kratom users and non-users living in Nam Phu Subdistrict, a special area that allows the traditional use of Kratom. The study subjects consisted of 581 individuals aged 18 and above. Binary logistic regression was used to determine an association between Kratom use and serum lipid level.
The findings revealed an association between Kratom use and an elevated HDL level (≥60 mg/dL) with an adjusted OR of 1.82 (95% CI, 1.17-2.8), and an association between Kratom use and a triglyceride level <90 mg/dL with an adjusted OR of 1.75 (95% CI; 1.17-2.63). There were no associations between Kratom use and LDL as well as total cholesterol level.
This study provided additional evidence of Kratom use and a favorable lipid profile. Prevention of coronary heart disease or cerebrovascular disease via an improvement in the lipid profile may be a future pharmaceutical application of Kratom.
本研究旨在探讨使用 kratom 与血清脂质水平之间的关联。
本研究比较了生活在允许传统使用 kratom 的特殊地区南富分区的 kratom 用户和非用户的血清脂质谱。研究对象包括581名18岁及以上的个体。采用二元逻辑回归分析来确定使用 kratom 与血清脂质水平之间的关联。
研究结果显示，使用 kratom 与高密度脂蛋白水平升高（≥60 mg/dL）之间存在关联，调整后的比值比为1.82（95%置信区间，1.17 - 2.8）；使用 kratom 与甘油三酯水平<90 mg/dL之间存在关联，调整后的比值比为1.75（95%置信区间；1.17 - 2.63）。使用 kratom 与低密度脂蛋白以及总胆固醇水平之间无关联。
本研究为使用 kratom 与良好的脂质谱提供了更多证据。通过改善脂质谱预防冠心病或脑血管疾病可能是 kratom 未来的药物应用方向。
