Neff Alison M, Flaws Jodi A
Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Curr Opin Endocr Metab Res. 2021 Jun;18:35-47. doi: 10.1016/j.coemr.2021.01.004. Epub 2021 Feb 10.
Endocrine disrupting chemicals pose a threat to health and reproduction. Plasticizers such as phthalates and bisphenols are particularly problematic because they are present in many consumer products and exposure can begin in utero and continue throughout the lifetime of the individual. Evidence suggests that these chemicals can have ancestral and transgenerational effects, making them a huge public health concern for the reproductive health of current and future generations. Studies performed in rodents or using rodent- or human-derived tissues have been critical for understanding the toxic effects of plasticizers on the ovary and their mechanisms of action. This review addresses current in vitro and rodent-based in vivo studies investigating the effects of bisphenols and phthalates on ovarian health, female reproduction, and correlations between human exposure and reproductive pathologies.
内分泌干扰化学物质对健康和生殖构成威胁。邻苯二甲酸盐和双酚等增塑剂问题尤为突出，因为它们存在于许多消费品中，个体在子宫内就可能开始接触，并持续一生。有证据表明，这些化学物质会产生代际和跨代效应，这使其成为当代及后代生殖健康的重大公共卫生问题。在啮齿动物身上或使用源自啮齿动物或人类的组织进行的研究，对于理解增塑剂对卵巢的毒性作用及其作用机制至关重要。本综述探讨了当前基于体外和啮齿动物的体内研究，这些研究调查了双酚和邻苯二甲酸盐对卵巢健康、女性生殖以及人类接触与生殖病理之间的相关性。
