Salomon Jeffrey, Ericsson Aaron, Price Amber, Manithody Chandrashekhara, Murry Daryl J, Chhonker Yashpal S, Buchanan Paula, Lindsey Merry L, Singh Amar B, Jain Ajay K
Department of Pediatrics, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
JACC Basic Transl Sci. 2021 Mar 3;6(4):311-327. doi: 10.1016/j.jacbts.2020.12.012. eCollection 2021 Apr.
There are no data evaluating the microbiome in congenital heart disease following cardiopulmonary bypass. The authors evaluated patients with congenital heart disease undergoing cardiopulmonary bypass and noncardiac patients undergoing surgery without bypass. Patients with congenital heart disease had differences in baseline microbiome compared with control subjects, and this was exacerbated following surgery with bypass. Markers of barrier dysfunction were similar for both groups at baseline, and surgery with bypass induced significant intestinal barrier dysfunction compared with control subjects. This study offers novel evidence of alterations of the microbiome in congenital heart disease and exacerbation along with intestinal barrier dysfunction following cardiopulmonary bypass.
目前尚无关于体外循环后先天性心脏病患者微生物组的评估数据。作者对接受体外循环的先天性心脏病患者和未接受体外循环的非心脏手术患者进行了评估。先天性心脏病患者与对照组相比，基线微生物组存在差异，并且在体外循环手术后这种差异进一步加剧。两组在基线时屏障功能障碍的标志物相似，但与对照组相比，体外循环手术导致明显的肠道屏障功能障碍。这项研究为先天性心脏病患者微生物组的改变以及体外循环后肠道屏障功能障碍加剧提供了新的证据。
