外泌体和脂肪细胞中的非编码RNA在癌症恶病质期间导致脂肪减少。
Non-coding RNAs in exosomes and adipocytes cause fat loss during cancer cachexia.
作者信息
Du Guannan, Zhang Yunan, Hu Shoushan, Zhou Xueer, Li Yi
机构信息
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, PR China.
出版信息
Noncoding RNA Res. 2021 Apr 15;6(2):80-85. doi: 10.1016/j.ncrna.2021.04.001. eCollection 2021 Jun.
Cancer Cachexia (CC) is a disease that changes various metabolisms in human body. Fat metabolism is significantly affected in CC, leading to fat loss. Non-coding RNAs (ncRNAs) in adipocytes and exosomes secreted by tumor play an important role in fat loss. However, there is no related reviews summarizing how ncRNAs contribute to fat loss during CC. This review screens recent articles to summarize how ncRNAs are packaged, transported in exosomes, and play the role in fat loss. Not only does this review summarize the mechanisms, we also point out the research orientations in the future.
癌症恶病质（CC）是一种改变人体多种代谢的疾病。CC会显著影响脂肪代谢，导致脂肪流失。脂肪细胞中的非编码RNA（ncRNAs）以及肿瘤分泌的外泌体在脂肪流失中起重要作用。然而，目前尚无相关综述总结ncRNAs在CC期间如何导致脂肪流失。本综述筛选了近期文章，以总结ncRNAs如何被包裹、在外泌体中运输以及在脂肪流失中发挥作用。本综述不仅总结了相关机制，还指出了未来的研究方向。
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