Koury Gisele V H, da S Araújo Francisca C R, Costa Kauê M, da Silva Filho Manoel
Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil.
National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD.
Mayo Clin Proc Innov Qual Outcomes. 2021 Jan 13;5(2):241-252. doi: 10.1016/j.mayocpiqo.2020.09.007. eCollection 2021 Apr.
To improve the diagnostic efficiency of current tests for auditory processing disorders (APDs) by creating new test signals using digital filtering methods.
We conducted a prospective study from August 1, 2014, to August 31, 2019, using 3 low speech redundancy tests with novel test signals that we created with specially designed digital filters: the binaural resynthesis test and the low pass and high pass filtered speech tests. We validated and optimized these new tests, then applied them to healthy individuals across different age groups to examine how age affected performance and to children with APD before and after acoustically controlled auditory training (ACAT) to assess clinical improvement after treatment.
We found a progressive increase in performance accuracy with less restrictive filters (<.001) and with increasing age for all tests (<.001). Our results suggest that binaural resynthesis and auditory closure mature at similar rates. We also demonstrate that the new tests can be used for the diagnosis of APD and for the monitoring of ACAT effects. Interestingly, we found that patients having the most severe deficits also benefited the most from ACAT (<.001).
We introduce a method that substantially improves current diagnostic tools for APD. In addition, we provide information on auditory processing maturation in normal development and validate that our method can detect APD-related deficits and ACAT-induced improvements in auditory processing.
通过使用数字滤波方法创建新的测试信号，提高当前听觉处理障碍（APD）测试的诊断效率。
我们于2014年8月1日至2019年8月31日进行了一项前瞻性研究，使用了3种低言语冗余测试，这些测试采用了我们用专门设计的数字滤波器创建的新型测试信号：双耳再合成测试以及低通和高通滤波言语测试。我们对这些新测试进行了验证和优化，然后将它们应用于不同年龄组的健康个体，以研究年龄如何影响测试表现，并应用于接受声学控制听觉训练（ACAT）前后的APD儿童，以评估治疗后的临床改善情况。
我们发现，对于所有测试，使用限制较少的滤波器时（<.001）以及随着年龄增长（<.001），测试表现的准确性都在逐步提高。我们的结果表明，双耳再合成和听觉闭合以相似的速度成熟。我们还证明，这些新测试可用于APD的诊断以及ACAT效果的监测。有趣的是，我们发现缺陷最严重的患者从ACAT中受益也最大（<.001）。
我们介绍了一种可大幅改进当前APD诊断工具的方法。此外，我们提供了正常发育过程中听觉处理成熟度的信息，并验证了我们的方法能够检测与APD相关的缺陷以及ACAT引起的听觉处理改善情况。
