Azab Mohammed A, Azzam Ahmed Y
Department of Neurosurgery, Cairo University Faculty of Medicine, Cairo, Egypt.
October 6 University Faculty of Medicine, Giza, Egypt.
Brain Disord. 2021 Jun;2:100012. doi: 10.1016/j.dscb.2021.100012. Epub 2021 May 9.
The coronavirus pandemic has affected many health care services worldwide since the emergence of the first case in Wuhan. Surgical neuro-oncology care is a fundamental part of hospital services, making it susceptible to strategic changes amid the COVID-19 pandemic.
An electronic search on several databases (PubMed/Medline, Scopus, and Google Scholar) from the beginning of the pandemic to the end of 2020, each paper was reviewed independently. The publication inclusion and exclusion criteria were done using Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines.
Eight studies were found to be eligible for our meta-analysis. Most of the studies were on a retrospective basis, except one which was retrospective and prospective. An overall of 951 glioma patients' were included for surgical admission from the beginning of the pandemic until 2020. Seventy-four patients' had mortality outcomes, and 250 patients had complications for both surgical admitted and non-surgical admitted purposes.
To our knowledge, we made the first systematic review and meta-analysis regarding the management of glioma patients' during the pandemic of COVID-19. Our main findings are that the number of surgical admissions for glioma patients' did not significantly differ between COVID-19 negative and COVD-19 positive cases; however, surprisingly, we found that both overall complications and mortality outcomes were more significant COVID-19 negative patients' from the reported studies.
自武汉出现首例病例以来，冠状病毒大流行已影响到全球许多医疗服务。外科神经肿瘤护理是医院服务的重要组成部分，在新冠疫情期间容易受到战略调整的影响。
在几个数据库（PubMed/Medline、Scopus和谷歌学术）上从疫情开始到2020年底进行电子检索，每篇论文都独立进行评审。使用系统评价和Meta分析的首选报告项目（PRISMA）指南确定出版物的纳入和排除标准。
发现八项研究符合我们的Meta分析要求。除一项研究兼具回顾性和前瞻性外，大多数研究是回顾性的。从疫情开始到2020年，总共纳入了951例因手术入院的胶质瘤患者。74例患者有死亡结局，250例患者因手术入院和非手术入院目的出现并发症。
据我们所知，我们首次对新冠疫情期间胶质瘤患者的管理进行了系统评价和Meta分析。我们的主要发现是，新冠病毒阴性和阳性病例中，胶质瘤患者的手术入院人数没有显著差异；然而，令人惊讶的是，从报告的研究中我们发现，新冠病毒阴性患者的总体并发症和死亡结局更为显著。
