College of Animal Sciences, Zhejiang University, Hangzhou, China.
Nutr Rev. 2022 Jan 10;80(2):165-177. doi: 10.1093/nutrit/nuab018.
Nondigestible fermentable carbohydrates (NDFCs) can be fermented by microbiota, thereby yielding metabolites that have a beneficial role in the prevention and treatment of obesity and its complications. However, to our knowledge, no meta-analysis has been conducted to evaluate the effects of NDFCs on obesity.
To conduct a meta-analysis of randomized controlled trials (RCTs) to summarize existing evidence on the effects of numerous NDFCs on adiposity and cardiovascular risk factors in adults with overweight or obesity with ≥2 weeks of follow-up.
The following databases were searched: MEDLINE, Embase, and CINAHL.
Seventy-seven RCTs with 4535 participants were identified for meta-analysis from the 3 databases.
The findings suggest that increased intake of NDFCs is significantly effective in reducing body mass index by 0.280 kg/m2, weight by 0.501 kg, hip circumference by 0.554 cm, waist circumference by 0.649 cm, systolic blood pressure by 1.725 mmHg, total cholesterol by 0.36 mmol/L, and low-density lipoprotein by 0.385 mmol/L, with evidence of moderate-to-high quality.
Convincing evidence from meta-analyses of RCTs indicates that increased NDFC intake improves adiposity, blood lipid levels, and systolic blood pressure in people with overweight and obesity.
不可消化的可发酵碳水化合物（NDFCs）可被微生物群发酵，从而产生具有预防和治疗肥胖及其并发症作用的代谢物。然而，据我们所知，尚未进行荟萃分析来评估 NDFC 对肥胖的影响。
对随机对照试验（RCT）进行荟萃分析，以总结现有证据，评估多种 NDFC 对超重或肥胖成年人的肥胖和心血管危险因素的影响，随访时间≥2 周。
检索了 MEDLINE、Embase 和 CINAHL 这三个数据库。
从这三个数据库中确定了 77 项 RCT 进行荟萃分析，涉及 4535 名参与者。
研究结果表明，增加 NDFC 的摄入量可显著有效降低 0.280kg/m2 的体重指数、0.501kg 的体重、0.554cm 的臀围、0.649cm 的腰围、1.725mmHg 的收缩压、0.36mmol/L 的总胆固醇和 0.385mmol/L 的低密度脂蛋白，证据质量为中至高。
RCT 荟萃分析的有力证据表明，增加 NDFC 的摄入量可改善超重和肥胖人群的肥胖、血脂水平和收缩压。
