The Precision Medicine Laboratory, The First People's Hospital of Qinzhou, Qinzhou, China.
Clin Genet. 2021 Sep;100(3):248-257. doi: 10.1111/cge.13998. Epub 2021 Jun 2.
With the rapid development of modern medical technology, information data modeling has been gradually applied to clinical diagnosis and treatment. Precision medicine is an important approach that focuses on individual patients in terms of their own characteristics, genomic information, proteomics and even social environments. Genome-wide high-throughput technologies, including DNA-seq, RNA-seq, exosome-seq…, contribute enormous amounts of molecular data to aid in diagnosis and analysis. Here, we review the developmental history of different next-generation sequencing platforms, introduce their applications in different tumor diagnosis and therapy, and further discuss the remaining challenges in precision medicine.
随着现代医学技术的快速发展，信息数据建模已逐渐应用于临床诊断和治疗。精准医学是一种重要的方法，它侧重于针对个体患者的自身特点、基因组信息、蛋白质组学甚至社会环境。全基因组高通量技术，包括 DNA-seq、RNA-seq、外泌体-seq……为辅助诊断和分析提供了大量分子数据。在这里，我们回顾了不同下一代测序平台的发展历史，介绍了它们在不同肿瘤诊断和治疗中的应用，并进一步讨论了精准医学中存在的挑战。
