Bălună R, Tarnavschi R, Barac D, Belascu I, Georgescu H
Department of Immunology, V. Babes Institute, Bucharest, Romania.
Med Interne. 1988 Jan-Mar;26(1):85-90.
Serum fibronectin (Fn) level was serially determined in nineteen septic patients. Fn concentration was found significantly decreased in septic patients (mean +/- SE, 120 +/- 11 micrograms/ml) as compared to the control (205 +/- 11 micrograms/ml). The decrease of Fn was correlated with the severity of sepsis; it was persistent and more important in severe septic cases. The lowest Fn concentration was found in nonsurviving patients (78 +/- 18 micrograms/ml). Serum Fn level may reflect the degree of organ failure and predict the evolution of sepsis.
对19名脓毒症患者连续测定血清纤连蛋白（Fn）水平。发现脓毒症患者的Fn浓度（均值±标准误，120±11微克/毫升）与对照组（205±11微克/毫升）相比显著降低。Fn的降低与脓毒症的严重程度相关；在严重脓毒症病例中，这种降低持续存在且更为明显。在未存活患者中发现最低的Fn浓度（78±18微克/毫升）。血清Fn水平可能反映器官衰竭的程度并预测脓毒症的进展。
