Department of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Department of Anesthesiology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.
J Alzheimers Dis. 2021;82(1):149-157. doi: 10.3233/JAD-210132.
Silent information-regulated transcription factor 1 (SIRT1) is the most prominent and widely studied member of the sirtuins (a family of mammalian class III histone deacetylases). It is a nuclear protein, and the deacetylation of the peroxisome proliferator-activated receptor coactivator-1 has been extensively implicated in metabolic control and mitochondrial biogenesis and is the basis for studies into its involvement in caloric restriction and its effects on lifespan. The present study discusses the potentially protective mechanism of SIRT1 in the regulation of the mitochondrial biogenesis and autophagy involved in the modulation of Alzheimer's disease, which may be correlated with the role of SIRT1 in affecting neuronal morphology, learning, and memory during development; regulating metabolism; counteracting stress responses; and maintaining genomic stability. Drugs that activate SIRT1 may offer a promising approach to treating Alzheimer's disease.
沉默信息调节转录因子 1（SIRT1）是 sirtuins（哺乳动物组 III 组蛋白去乙酰化酶家族）中最突出和广泛研究的成员。它是一种核蛋白，过氧化物酶体增殖物激活受体共激活因子-1 的去乙酰化作用广泛涉及代谢控制和线粒体生物发生，并且是研究其在热量限制及其对寿命影响中的作用的基础。本研究讨论了 SIRT1 在调节阿尔茨海默病中涉及的线粒体生物发生和自噬的潜在保护机制，这可能与 SIRT1 在发育过程中影响神经元形态、学习和记忆、调节代谢、对抗应激反应以及维持基因组稳定性中的作用有关。激活 SIRT1 的药物可能为治疗阿尔茨海默病提供一种有前途的方法。
