Movement Disorders Unit, Neurological Institute, Tel-Aviv Medical Center, Tel-Aviv, Israel.
Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
J Parkinsons Dis. 2021;11(3):1285-1296. doi: 10.3233/JPD-212624.
Inflammation is an integral part of neurodegeneration including in Parkinson's disease (PD). Ashkenazi Jews have high rates of genetic PD with divergent phenotypes among GBA-PD and LRRK2-PD. The role of inflammation in the prodromal phase of PD and the association with disease phenotype has yet to be elucidated.
To assess central and peripheral cytokines among PD patients with mutations in the LRRK2 and GBA genes and among non-manifesting carriers (NMC) of these mutations in order to determine the role of inflammation in genetic PD.
The following cytokines were assessed from peripheral blood and cerebrospinal fluid (CSF): TNF-α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10 and INF- γ. A comprehensive intake including general medical conditions, use of anti-inflammatory treatments, motor and cognitive assessments and additional laboratory measures were recorded, enabling the construction of the MDS probable prodromal score.
Data from 362 participants was collected: 31 idiopathic PD (iPD), 30 LRRK2-PD, 77 GBA-PD, 3 homozygote GBA-PD, 3 GBA-LRRK2-PD, 67 LRRK2-NMC, 105 GBA-NMC, 14 LRRK2-GBA-NMC, and 32 healthy controls. No between-group differences in peripheral or CSF cytokines were detected. No correlation between disease characteristics or risk for prodromal PD could be associated with any inflammatory measure.
In this study, we could not detect any evidence on dysregulated immune response among GBA and LRRK2 PD patients and non-manifesting mutation carriers.
炎症是神经退行性变的一个组成部分，包括帕金森病（PD）。阿什肯纳兹犹太人的 PD 遗传率很高，GBA-PD 和 LRRK2-PD 的表型存在差异。炎症在 PD 的前驱期的作用及其与疾病表型的关联尚不清楚。
评估 LRRK2 和 GBA 基因突变的 PD 患者以及这些突变的非表现型携带者（NMC）的中枢和外周细胞因子，以确定炎症在遗传 PD 中的作用。
从外周血和脑脊液（CSF）中评估以下细胞因子：TNF-α、IL-1β、IL-2、IL-4、IL-6、IL-8、IL-10 和 INF-γ。记录了全面的摄入情况，包括一般医疗状况、抗炎治疗的使用、运动和认知评估以及其他实验室措施，从而构建了 MDS 可能的前驱评分。
共收集了 362 名参与者的数据：31 名特发性 PD（iPD）、30 名 LRRK2-PD、77 名 GBA-PD、3 名纯合 GBA-PD、3 名 GBA-LRRK2-PD、67 名 LRRK2-NMC、105 名 GBA-NMC、14 名 LRRK2-GBA-NMC 和 32 名健康对照。外周或 CSF 细胞因子在各组之间无差异。未发现疾病特征或前驱 PD 风险与任何炎症指标之间存在相关性。
在这项研究中，我们无法在 GBA 和 LRRK2 PD 患者和非表现型突变携带者中检测到任何失调的免疫反应证据。
