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Hypoalbuminemia in COVID-19: assessing the hypothesis for underlying pulmonary capillary leakage.COVID-19 中的低白蛋白血症:评估潜在肺毛细血管渗漏假说。
J Intern Med. 2021 Jun;289(6):861-872. doi: 10.1111/joim.13208. Epub 2021 Jan 7.
2
Prognostic Value of Computed Tomography Versus Echocardiography Derived Right to Left Ventricular Diameter Ratio in Acute Pulmonary Embolism.计算机断层扫描与超声心动图右心室到左心室直径比值在急性肺栓塞中的预后价值。
Am J Med Sci. 2021 Apr;361(4):445-450. doi: 10.1016/j.amjms.2020.07.008. Epub 2020 Jul 8.
3
Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome.中性粒细胞胞外诱捕网在新冠病毒疾病急性呼吸窘迫综合征的免疫性血栓形成中发挥作用。
Blood. 2020 Sep 3;136(10):1169-1179. doi: 10.1182/blood.2020007008.
4
COVID-19 and its implications for thrombosis and anticoagulation.新型冠状病毒肺炎及其对血栓形成和抗凝的影响。
Blood. 2020 Jun 4;135(23):2033-2040. doi: 10.1182/blood.2020006000.
5
2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS).2019年欧洲心脏病学会(ESC)与欧洲呼吸学会(ERS)合作制定的急性肺栓塞诊断和管理指南。
Eur Heart J. 2020 Jan 21;41(4):543-603. doi: 10.1093/eurheartj/ehz405.
6
Prognostic models in acute pulmonary embolism: a systematic review and meta-analysis.急性肺栓塞的预后模型:系统评价与荟萃分析
BMJ Open. 2016 Apr 29;6(4):e010324. doi: 10.1136/bmjopen-2015-010324.
7
Prognostic accuracy of clinical prediction rules for early post-pulmonary embolism all-cause mortality: a bivariate meta-analysis.肺栓塞后早期全因死亡率临床预测规则的预后准确性:双变量荟萃分析
Chest. 2015 Apr;147(4):1043-1062. doi: 10.1378/chest.14-1888.
8
Comparison of the unstructured clinician gestalt, the wells score, and the revised Geneva score to estimate pretest probability for suspected pulmonary embolism.比较非结构化临床医生的整体印象、Wells评分和修订后的日内瓦评分,以评估疑似肺栓塞的验前概率。
Ann Emerg Med. 2013 Aug;62(2):117-124.e2. doi: 10.1016/j.annemergmed.2012.11.002. Epub 2013 Feb 21.
9
Short-term mortality in acute pulmonary embolism: clot burden and signs of right heart dysfunction at CT pulmonary angiography.CT 肺动脉造影中急性肺栓塞的短期死亡率:血栓负荷和右心功能障碍的征象。
Radiology. 2012 Oct;265(1):283-93. doi: 10.1148/radiol.12110802.
10
The validation and reproducibility of the pulmonary embolism severity index.肺动脉栓塞严重指数的验证和可重复性。
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COVID-19 相关静脉血栓栓塞症的临床-放射学相关性:多学科研究的初步结果。

Clinical-radiological correlations in COVID-19-related venous thromboembolism: Preliminary results from a multidisciplinary study.

机构信息

Division of Internal Medicine, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, University of Milan, Milan, Italy.

Division of Anesthesiology and Intensive Care, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, University of Milan, Milan, Italy.

出版信息

Int J Clin Pract. 2021 Sep;75(9):e14370. doi: 10.1111/ijcp.14370. Epub 2021 May 29.

DOI:10.1111/ijcp.14370
PMID:33998752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8236936/
Abstract

INTRODUCTION

Among the multiple complex pathophysiological mechanisms underlying COVID-19 pneumonia, immunothrombosis has been shown to play a key role. One of the most dangerous consequences of the prothrombotic imbalance is the increased incidence of micro- and macrothrombotic phenomena, especially deep vein thrombosis (DVT) and pulmonary embolism (PE).

METHODS

We investigated the correlation between radiological and clinical-biochemical characteristics in a cohort of hospitalised COVID-19 patients.

RESULTS

PE was confirmed in 14/61 (23%) patients, five (35.7%) had DVT. The radiographic findings, quantified by Qanadli score calculated on CT angiography, correlated with the clinical score and biochemical markers. The ratio between the right and left ventricle diameter measured at CT angiography correlated with the length of hospital stay.

CONCLUSION

In our cohort radiological parameters showed a significant correlation with clinical prognostic indices and scores, thus suggesting that a multidisciplinary approach is advisable in the evaluation of PE in COVID-19 patients.

摘要

简介

在导致 COVID-19 肺炎的多种复杂病理生理机制中,免疫血栓形成被证明起着关键作用。促凝失衡最危险的后果之一是微血栓和大血栓现象的发生率增加,特别是深静脉血栓形成(DVT)和肺栓塞(PE)。

方法

我们调查了住院 COVID-19 患者队列中放射学和临床生物化学特征之间的相关性。

结果

14/61(23%)的患者证实有 PE,5 例(35.7%)有 DVT。通过 CT 血管造影计算的 Qanadli 评分定量的影像学发现与临床评分和生化标志物相关。CT 血管造影测量的右心室和左心室直径比值与住院时间相关。

结论

在我们的队列中,放射学参数与临床预后指数和评分有显著相关性,因此建议对 COVID-19 患者的 PE 进行多学科评估。