Departamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México CDMX, Mexico.
Departamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México CDMX, Mexico.
J Nutr Biochem. 2021 Oct;96:108768. doi: 10.1016/j.jnutbio.2021.108768. Epub 2021 May 14.
The increase in incidence and prevalence of metabolic diseases, such as diabetes, obesity, and metabolic syndrome, is a health problem worldwide. Nutritional strategies that can impact on mitochondrial activity represent a novel and effective option to modulate energy expenditure and energetic metabolism in cells and tissues and could be used as adjuvant treatments for metabolic-associated disorders. Dietary bioactive compounds also known as "food bioactives" have proven to exert multiple health benefits and counteract metabolic alterations. In the last years, it has been consistently reported that the modulation of mitochondrial function represents one of the mechanisms behind the bioactive compounds-dependent health improvements. In this review, we focus on gathering, summarizing, and discussing the evidence that supports the effect of dietary bioactive compounds on mitochondrial activity and the relation of these effects in the pathological context. Despite the evidence presented here on in vivo and in vitro effects, more studies are needed to determine their effectiveness in humans.
代谢性疾病（如糖尿病、肥胖症和代谢综合征）的发病率和患病率不断上升，这是一个全球性的健康问题。能够影响线粒体活性的营养策略代表了一种新颖而有效的选择，可以调节细胞和组织中的能量消耗和能量代谢，可作为代谢相关疾病的辅助治疗方法。膳食生物活性化合物也称为“食物生物活性物质”，已被证明具有多种健康益处，并能对抗代谢紊乱。在过去的几年中，一直有报道称，调节线粒体功能是生物活性化合物依赖于健康改善的机制之一。在这篇综述中，我们重点收集、总结和讨论支持膳食生物活性化合物对线粒体活性的影响及其在病理情况下的关系的证据。尽管这里提出了关于体内和体外作用的证据，但仍需要更多的研究来确定它们在人类中的有效性。
