Institut für Biostatistik und Informatik in Medizin und Alternsforschung, Universitätsmedizin Rostock, Germany.
Interdisziplinäre Fakultät, Department AGIS (Altern des Individuums und der Gesellschaft), Universität Rostock, Germany.
Aging Dis. 2024 Apr 1;15(2):601-611. doi: 10.14336/AD.2023.0619.
Climate extremes and rising energy prices present interconnected global health risks. Technical solutions can be supplemented with biomedical approaches to promote healthy longevity in hot and cold conditions. In summer, reducing basal metabolic rate through mild caloric restriction or CR mimetics, such as resveratrol, can potentially be used to lower body temperature. In winter, activating brown adipose tissue (BAT) for non-shivering thermogenesis and improved metabolic health can help adaptation to colder environments. Catechins found in green tea and in other food could be alternatives to drugs for these purposes. This review examines and discusses the biomedical evidence supporting the use of CR mimetics and BAT activators for health benefits amid increasingly extreme temperatures.
气候极端和能源价格上涨带来了相互关联的全球健康风险。可以将生物技术方法补充到技术解决方案中，以促进在炎热和寒冷条件下的健康长寿。在夏季，可以通过适度的热量限制或白藜芦醇等 CR 模拟物来降低基础代谢率，从而潜在地降低体温。在冬季，激活棕色脂肪组织（BAT）进行非颤抖性产热和改善代谢健康有助于适应较冷的环境。绿茶和其他食物中的儿茶素可能是这些目的的药物替代品。本综述检查和讨论了支持使用 CR 模拟物和 BAT 激活剂以在日益极端的温度下获得健康益处的生物医学证据。
