NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, California 92037, USA.
Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, California 92093, USA.
Cold Spring Harb Perspect Biol. 2021 Aug 2;13(8):a038075. doi: 10.1101/cshperspect.a038075.
Immunological memory is a hallmark of adaptive immunity that confers long-lasting protection from reinfections. Memory CD8 T cells provide protection by actively scanning for their cognate antigen and migrating into inflamed tissues. Trafficking patterns of CD8 T cells are also a major determinant of cell fate outcomes during differentiation into effector and memory cell states. CD8 T-cell trafficking must therefore be dynamically and tightly regulated to ensure that CD8 T cells arrive at the correct locations and differentiate to acquire appropriate effector functions. This review aims to discuss the importance of CD8 T-cell trafficking patterns in regulating effector and memory differentiation, maintenance, and reactivation.
免疫记忆是适应性免疫的一个标志,它能提供对再感染的长期保护。记忆 CD8 T 细胞通过主动扫描其同源抗原并迁移到炎症组织中来提供保护。CD8 T 细胞的迁移模式也是决定分化为效应细胞和记忆细胞状态时细胞命运结果的主要因素。因此,必须对 CD8 T 细胞的迁移进行动态和严格的调节,以确保 CD8 T 细胞到达正确的位置并分化以获得适当的效应功能。本综述旨在讨论 CD8 T 细胞迁移模式在调节效应细胞和记忆细胞分化、维持和激活中的重要性。