合成士兵：将 T 细胞转化为不朽的战士。

Synthetic soldiers: Turning T cells into immortal warriors.

机构信息

Marble Therapeutics , Boston, MA, USA.

Cancer Data Science Laboratory, National Cancer Institute, National Institutes of Health , Bethesda, MD, USA.

出版信息

J Exp Med. 2024 May 6;221(5). doi: 10.1084/jem.20240258. Epub 2024 Apr 18.

DOI:10.1084/jem.20240258

PMID:38634804

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11032022/

Abstract

The creation of synthetic T cell states has captivated the field of cell-based therapies. Wang et al. (https://doi.org/10.1084/jem.20232368) describe how disruption of BCOR and ZC3H12A unleashes anti-tumor T cells with unprecedented lifespan and killer instinct. Are we witnessing the birth of immortal super-soldiers in medicine?

摘要

人工合成 T 细胞状态的创造吸引了基于细胞疗法的领域。Wang 等人（https://doi.org/10.1084/jem.20232368）描述了如何破坏 BCOR 和 ZC3H12A 来释放具有前所未有的寿命和杀伤本能的抗肿瘤 T 细胞。我们是否正在见证医学中不朽超级战士的诞生？